Publications by authors named "Theshani A De Silva"
We report a 45-year-old man with medically refractory ulcerative colitis with superimposed colonic malakoplakia, presumed related to chronic use of azathioprine and biologics. This is the first reported case of malakoplakia in a patient requiring high doses of combination therapy. Treatment of malakoplakia is not standardized, but can involve systemic antibiotics, or surgical resection, which in this case resulted in proctocolectomy.
View Article and Find Full Text PDFArticle Synopsis
- A systematic review assessed the effectiveness of various medical therapies for treating and preventing pouchitis based on randomized controlled trials (RCTs) published up to March 2022.
- The review included 20 RCTs with a total of 830 participants, examining the outcomes of different treatments like ciprofloxacin, metronidazole, budesonide enemas, and De Simone Formulation in both acute and chronic pouchitis cases.
- Key findings showed that De Simone Formulation and vedolizumab had moderate evidence of effectiveness, while the benefits of other therapies were less certain, indicating a need for more research on pouchitis treatments.
Background And Aims: Treatment options for proctitis are limited. To assist trial design for novel therapeutics, we conducted a systematic review and meta-analysis of proctitis randomized controlled trials [RCTs] to quantify placebo rates and identify factors influencing them.
Methods: We searched MEDLINE, EMBASE and CENTRAL from inception to June 2021.