Publications by authors named "Therese O'Toole"

Portal system thrombosis is a rare but potentially fatal complication of splenectomy in dogs. The mechanism behind development of post-operative portal system thrombosis is unclear but may include alterations of portal blood flow following surgery, acquired hypercoagulability and endothelial dysfunction. The aim of the study was to evaluate hemostatic biomarkers in hemodynamically stable (heart rate <130 beats/min, blood lactate < 2.

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Objective: To describe a population of dogs with hops toxicosis, including clinical signs observed, treatments performed, patient outcome, and overall prognosis. Clinical findings and treatment interventions were evaluated for their potential effects on outcome. This study also aims to review hops toxicosis and treatment options.

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Background: Aortic thrombosis (ATh) is an uncommon condition in dogs, with limited understanding of risks factors, outcomes, and treatments.

Objectives/hypothesis: To describe potential risk factors, outcome, and treatments in dogs with ATh.

Animals: Client-owned dogs with a diagnosis of ATh based on ultrasonographic or gross necropsy examination.

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Objective: To describe acute compartment syndrome (CS) of the muscles of mastication in a working dog associated with a traumatic training event.

Case Summary: A 2.5-year-old male Belgian Malinois was evaluated for acute blindness, severe diffuse swelling of the head, and inability to close the jaw following a traumatic incident during a bite training drill.

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In this article, we consider the implications of the 'Prevent' strand of the government's counter-terrorism strategy for the UK state's engagement with Muslims. We argue that the logics of Prevent have been highly problematic for state-Muslim engagement. Nevertheless, we suggest that the characterisation of state approaches to engaging Muslims as a form of discipline is incomplete without an analysis of: first, differences in practices, habits and perspectives across governance domains; second, variations in approach and implementation between levels of governance; and third, the agency of Muslims who engage with the state.

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Objective: To describe a case of acute tracheal compression due to a dorsal tracheal membrane abscess in a dog.

Case Summary: A 3-year-old intact male Bluetick Coonhound presented for evaluation of 36 hours of marked inspiratory dyspnea and stridor. A radiographic diagnosis of tracheal collapse was made on thoracic radiographs, which was confirmed to be static compression by tracheoscopy.

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Objective: To describe transfusion practices for treatment of dogs hospitalized because of traumatic injuries.

Design: Retrospective case series.

Animals: 125 client-owned dogs.

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Objective: To describe transfusion practices for treatment of dogs undergoing splenectomy for splenic masses.

Design: Retrospective case series.

Animals: 542 client-owned dogs.

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Objective: To determine the perioperative mortality rate, causes of death, and risk factors for perioperative death in dogs undergoing splenectomy for splenic mass lesions.

Design: Retrospective case series.

Animals: 539 dogs.

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Objective: To determine the incidence of acute traumatic coagulopathy in dogs suffering severe trauma and to investigate the association of markers of hypoperfusion with coagulation abnormalities.

Design: A prospective observational study performed June, 2009 to February, 2011.

Setting: A university teaching hospital.

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Objective: To evaluate whole blood hemostasis by means of thromboelastography in dogs with primary immune-mediated hemolytic anemia (IMHA) to determine whether these dogs had evidence of hypercoagulability prior to the administration of immunosuppressant medications, blood transfusion products, or anticoagulant agents.

Design: Evaluation study.

Animals: 11 client-owned dogs admitted to a teaching hospital for management of primary IMHA and 20 clinically normal dogs.

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Objective: To determine the utility of human intravenous immunoglobulin (hIVIG) for the initial treatment of canine immune-mediated hemolytic anemia (IMHA).

Design: Blinded, randomized, clinical trial.

Setting: Veterinary teaching hospital.

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Objective: To describe the use of IV and oral mycophenolate mofetil (MMF) as adjunctive therapy in 3 dogs with severe generalized myasthenia gravis.

Case Series Summary: Three dogs suffering from severe generalized myasthenia gravis as confirmed by acetylcholine antibody titers were treated with MMF as part of their treatment regimens. All 3 dogs had radiographic evidence of megaesophagus and suffered from severe regurgitation.

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Thrombi and thromboemboli are organized fibrin clots that may result in partial or total occlusion of arterial or venous blood flow. Consequences of occlusion of blood flow vary with the organ affected.Thrombolytic agents have been used for the dissolution of pathologic thrombi since the 1980s.

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Four dogs were examined because of vomiting of 7 to 48 hours' duration. Gas-distended segments of intestine were identified radiographically in all dogs, but the affected portion of the intestinal tract could not always be identified as the colon. Volvulus of the colon was diagnosed during surgery in all 4 dogs.

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A 3-year-old female German Shepherd Dog was evaluated for progressive mental obtundation and vestibular signs. Central nervous system cryptococcosis was diagnosed on the basis of growth of Cryptococcus neoformans in fungal culture of CSF, as well as detection of the organism in CSF via microscopy. Cryptococcal capsular latex antigen agglutination titer was 1:262,144 in CSF and 1:1,048,576 in serum samples.

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