Expecting parents' use of digital sources in preparation for parenthood in a digitalised society - a systematic review.

Background: In today's society, people are experiencing the rapid development of digitalisation. Expecting parents may have difficulties evaluating the information online; they are not always sure which sources of information are trustworthy, and this exacerbates their feelings of anxiety. More research is needed to broaden the knowledge about how their use of digital sources may influence their health.

Controlled outcome of Hirschsprung's disease beyond adolescence: a single center experience.

Purpose: The aim of this study was to assess the function and quality of life of Hirschsprung's Disease (HD) beyond adolescence and relate it to matched controls.

Methods: All 203 patients diagnosed with HD at our department from 1961 to 1995 were identified. 21 had died, 43 had unclear diagnosis and 16 could not be traced.

Correction to 'Hypoxia increases the risk of egg predation in a nest-guarding fish'.

[This corrects the article DOI: 10.1098/rsos.160326.

Hypoxia increases the risk of egg predation in a nest-guarding fish.

For fish with parental care, a nest should meet both the oxygenation needs of the eggs and help protect them against predators. While a small nest opening facilitates the latter, it impedes the former and vice versa. We investigated how the presence of potential egg predators in the form of shore crabs affects nest building, egg fanning, defensive displays and filial cannibalism of egg-guarding male sand gobies under two levels of dissolved oxygen.

Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations.

Background: The antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have investigated whether ketoconazole affects the cellular uptake and hydrolysis of the endogenous cannabinoid receptor ligand anandamide (AEA).

Methodology/principal Findings: The effects of ketoconazole upon endocannabinoid uptake were investigated using HepG2, CaCo2, PC-3 and C6 cell lines.

Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans.

Objective: The effects of a promising new appetite suppressor named "thylakoids" (membrane proteins derived from spinach leaves) were examined in a single meal in man. Thylakoids inhibit the lipase/colipase hydrolysis of triacylglycerols in vitro and suppress food intake, decrease body-weight gain and raise the satiety hormone cholecystokinin (CCK) in rats, but their effects in man remain unclear. The aim of this study was to investigate whether thylakoids, when added to a test meal, affect appetite regulation and blood parameters in healthy individuals.