Publications by authors named "Therese L Dane"
Front Cell Neurosci
April 2023
Article Synopsis
- Intronic repeat expansions in the C9orf72 gene are major contributors to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), causing both loss-of-function and toxic gain-of-function effects.
- Small-molecule inhibitors of Type I protein arginine methyltransferases (PRMTs) have shown potential in protecting against toxicities in specific cell types, but their effects on human motor neurons have yet to be investigated.
- Research demonstrated that decreased C9orf72 levels increase the toxicity of polyGR15 in spinal motor neurons, and Type I PRMT inhibition can partially mitigate this toxicity, suggesting a therapeutic avenue for C9orf72-related ALS.
