Background And Objective: A selection of patients for a controlled clinical trial may be biased because of prior knowledge of the treatment. With randomized blocks of known or guessed lengths, some allocations can be predicted with certainty. Previously described methods determine the proportion of predictable cases for blocks of equal lengths.
View Article and Find Full Text PDFEur J Drug Metab Pharmacokinet
June 2005
The disposition of naltrexone (NLT) (REVIA), an opioid antagonist intended for patients with impaired renal function and with severe intractable itching refractory to regular antipruritic therapy, was characterized. Hemodialysis effects on both efficacy and elimination of NLT also were assessed. We developed a simple, sensitive and selective reverse-phase high-performance liquid chromatographic (HPLC) method for measuring NLT plasma concentration in hemodialysis patients treated to relieve pruritus.
View Article and Find Full Text PDFFrom October 2001, the Australian healthcare system has made provision for, in predefined circumstances, a domiciliary medication review service. This pharmaceutical care service provides a medication review for outpatients encountering (or who may encounter) difficulties with their treatments, and who are referred by their physician. The pharmacist is chosen by the outpatient.
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