Publications by authors named "Theresa Siekmann"
Article Synopsis
- AKT plays a significant role in cancer signaling, prompting extensive research into small molecule inhibitors that target it, with several currently in advanced clinical trials.
- A combined analysis using kinobeads and phosphoproteomics studied five AKT inhibitors in breast cancer cells, revealing common targets and identifying a large number of regulated phosphorylation sites linked to AKT signaling.
- From this study, a new network of AKT-related phosphoproteins was discovered, which includes important regulatory functions in mitosis and cytoskeleton organization, as well as a specific phosphorylation pattern that enhances autophagy when AKT is inhibited.
