Melodic Intonation Therapy for aphasia: A multi-level meta-analysis of randomized controlled trials and individual participant data.

Melodic Intonation Therapy (MIT) is a prominent rehabilitation program for individuals with post-stroke aphasia. Our meta-analysis investigated the efficacy of MIT while considering quality of outcomes, experimental design, influence of spontaneous recovery, MIT protocol variant, and level of generalization. Extensive literature search identified 606 studies in major databases and trial registers; of those, 22 studies-overall 129 participants-met all eligibility criteria.

GCN5 contributes to intracellular lipid accumulation in human primary cardiac stromal cells from patients affected by Arrhythmogenic cardiomyopathy.

Arrhythmogenic cardiomyopathy (ACM) is a genetic disease associated with sudden cardiac death and cardiac fibro-fatty replacement. Over the last years, several works have demonstrated that different epigenetic enzymes can affect not only gene expression changes in cardiac diseases but also cellular metabolism. Specifically, the histone acetyltransferase GCN5 is known to facilitate adipogenesis and modulate cardiac metabolism in heart failure.

Voice modulatory cues to structure across languages and species.

Voice modulatory cues such as variations in fundamental frequency, duration and pauses are key factors for structuring vocal signals in human speech and vocal communication in other tetrapods. Voice modulation physiology is highly similar in humans and other tetrapods due to shared ancestry and shared functional pressures for efficient communication. This has led to similarly structured vocalizations across humans and other tetrapods.

The Influence of Different Prosodic Cues on Word Segmentation.

A prerequisite for spoken language learning is segmenting continuous speech into words. Amongst many possible cues to identify word boundaries, listeners can use both transitional probabilities between syllables and various prosodic cues. However, the relative importance of these cues remains unclear, and previous experiments have not directly compared the effects of contrasting multiple prosodic cues.

Scaling Laws for Phonotactic Complexity in Spoken English Language Data.

Two prominent statistical laws in language and other complex systems are Zipf's law and Heaps' law. We investigate the extent to which these two laws apply to the linguistic domain of phonotactics-that is, to sequences of sounds. We analyze phonotactic sequences with different lengths within words and across word boundaries taken from a corpus of spoken English (Buckeye).

Non-native speaker pause patterns closely correspond to those of native speakers at different speech rates.

When speaking a foreign language, non-native speakers can typically be readily identified by their accents. But which aspects of the speech signal determine such accents? Speech pauses occur in all languages but may nonetheless vary in different languages with regard to their duration, number or positions in the speech stream, and therefore are one potential contributor to foreign speech production. The aim of this study was therefore to investigate whether non-native speakers pause 'with a foreign accent'.