Publications by authors named "Theresa M Desrochers"

Humans complete different types of sequences as a part of everyday life. These sequences can be divided into two important categories: those that are abstract, in which the steps unfold according to a rule at super-second to minute time scale, and those that are motor, defined solely by individual movements and their order which unfold at the sub-second to second timescale. For example, the sequence of making spaghetti consists of abstract tasks (preparing the sauce and cooking the noodles) and nested motor actions (stir pasta water).

View Article and Find Full Text PDF
Article Synopsis
  • The text discusses how sequential information is essential in daily activities, like figuring out when to get off public transport by noticing patterns in buildings.
  • It highlights a study on the monkey lateral prefrontal cortex (LPFC), particularly area 46, revealing it responds mainly to violations of abstract sequence rules, while other subregions respond to changes in periodicity and identity of images.
  • The findings suggest that different subregions of the LPFC are specialized for processing various aspects of stimuli, which may help in recognizing patterns and navigating complex tasks in daily life.
View Article and Find Full Text PDF

Completing sequences is part of everyday life. Many such sequences can be considered abstract - that is, defined by a rule that governs the order but not the identity of individual steps (e.g.

View Article and Find Full Text PDF

Each day, humans must parse visual stimuli with varying amounts of perceptual experience, ranging from incredibly familiar to entirely new. Even when choosing a novel to buy at a bookstore, one sees covers they have repeatedly experienced intermixed with recently released titles. Visual exposure to stimuli has distinct neural correlates in the lateral prefrontal cortex (LPFC) of nonhuman primates.

View Article and Find Full Text PDF

In everyday life, humans perform sequences of tasks. These tasks may be disrupted in people with obsessive-compulsive disorder (OCD). Symptoms, such as compulsions, can be considered sequential and often cause repetitions of tasks that disrupt daily living (e.

View Article and Find Full Text PDF

Unlabelled: Sequential information permeates daily activities, such as when watching for the correct series of buildings to determine when to get off the bus or train. These sequences include periodicity (the spacing of the buildings), the identity of the stimuli (the kind of house), and higher-order more abstract rules that may not depend on the exact stimulus (e.g.

View Article and Find Full Text PDF

Monitoring sequential information is an essential component of our daily lives. Many of these sequences are abstract, in that they do not depend on the individual stimuli, but do depend on an ordered set of rules (e.g.

View Article and Find Full Text PDF

Cognitive neuroscience currently conflates the study of serial responses (e.g., delay match to sample/nonsample, n-back) with the study of sequential operations.

View Article and Find Full Text PDF

In this issue of Neuron, Chiang et al. examine population coding of self-ordered sequences in prefrontal cortex. They find better decoding, more distributed information, and less variability when order is consistent.

View Article and Find Full Text PDF

Many fundamental human behaviors contain multiple sequences performed to reach a desired outcome, such as cooking. Reward is inherently associated with sequence completion and has been shown to generally enhance cognitive control. However, the impact of reward on cognitive sequence processing remains unexplored.

View Article and Find Full Text PDF

To engage with the world, we must regularly make predictions about the outcomes of physical scenes. How do we make these predictions? Recent computational evidence points to simulation-the idea that we can introspectively manipulate rich, mental models of the world-as one explanation for how such predictions are accomplished. However, questions about the potential neural mechanisms of simulation remain.

View Article and Find Full Text PDF

Everyday task sequences, such as cooking, contain overarching goals (completing the meal), subgoals (prepare vegetables), and motor actions (chopping). Such tasks generally are considered hierarchical because superordinate levels (e.g.

View Article and Find Full Text PDF

There has been growing interest in quantifying the proportion of women participating in scientific conferences, publications, and committees. Numbers reveal persistent disparities, but offer few cures to the root causes of the gender gaps in research. Toward remediation, we outline five lessons learned through organizing two conferences for Women in Neuroscience (WiN).

View Article and Find Full Text PDF

Cognitive control refers to our ability to choose courses of thought and action that achieve our goals over habitual but contextually inappropriate ones. Hierarchical control problems are those in which multiple goals or contextual contingency must be managed at once and related to one another. In the open-ended complexity of the real world, hierarchical control arguably characterizes most of the problems faced by our control systems.

View Article and Find Full Text PDF

When presented with a choice, organisms need to assimilate internal information with external stimuli and past experiences to rapidly and flexibly optimize decisions on a moment-to-moment basis. We hypothesized that increasing hunger intensity would curb expression of social behaviors such as mating or territorial aggression; we further hypothesized social interactions, reciprocally, would influence food consumption. We assessed competition between these motivations from both perspectives of mice within a resident-intruder paradigm.

View Article and Find Full Text PDF

An essential human skill is our capacity to monitor and execute a sequence of tasks in the service of an overarching goal. Such a sequence can be as mundane as making a cup of coffee or as complex as flying a fighter plane. Previously, we showed that, during sequential control, the rostrolateral prefrontal cortex (RLPFC) exhibits activation that ramps steadily through the sequence and is necessary for sequential task execution using fMRI in humans (Desrochers et al.

View Article and Find Full Text PDF

Our ability to plan and execute a series of tasks leading to a desired goal requires remarkable coordination between sensory, motor, and decision-related systems. Prefrontal cortex (PFC) is thought to play a central role in this coordination, especially when actions must be assembled extemporaneously and cannot be programmed as a rote series of movements. A central component of this flexible behavior is the moment-by-moment allocation of working memory and attention.

View Article and Find Full Text PDF

Frontal neocortex is thought to support our highest intellectual abilities, including our ability to plan and enact a sequence of tasks toward a desired goal. In everyday life, such task sequences are abstract in that they do not require consistent movement sequences and are often assembled "on the fly." Yet, remarkably little is known about the necessity of frontal sub-regions for such control.

View Article and Find Full Text PDF

Over a century of scientific work has focused on defining the factors motivating behavioral learning. Observations in animals and humans trained on a wide range of tasks support reinforcement learning (RL) algorithms as accounting for the learning. Still unknown, however, are the signals that drive learning in naive, untrained subjects.

View Article and Find Full Text PDF

Evidence suggests that lateral frontal cortex is hierarchically organized such that rostral frontal regions support more abstract representations than caudal regions. A recent fMRI study of language processing proposes that striatum may exhibit an analogous organization. We consider this hypothetical correspondence at both the cognitive and anatomical levels.

View Article and Find Full Text PDF

A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system that allows the independent movement of hundreds of electrodes chronically implanted in several cortical and subcortical structures.

View Article and Find Full Text PDF

Habits and rituals are expressed universally across animal species. These behaviors are advantageous in allowing sequential behaviors to be performed without cognitive overload, and appear to rely on neural circuits that are relatively benign but vulnerable to takeover by extreme contexts, neuropsychiatric sequelae, and processes leading to addiction. Reinforcement learning (RL) is thought to underlie the formation of optimal habits.

View Article and Find Full Text PDF