Publications by authors named "Theresa Jasion"
Background: Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore application of minimally invasive drug sampling techniques, such as dried blood spots (DBS), may enhance the enrollment of children in PK studies. The objectives of this study were to compare solithromycin concentrations in DBS with those in liquid plasma samples (LPS) and to quantify the effects of modeling DBS concentrations on the results of a population PK model.
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- Solithromycin is a new type of antibiotic being tested for community-acquired bacterial pneumonia in children, focusing on its pharmacokinetics (how the drug moves through the body) and safety.
- The study involved 84 children (from infants to 17 years old) who received the drug either through infusion or orally, with data combined from earlier adolescent studies for a thorough analysis.
- Overall, while the drug showed some minor side effects like diarrhea and infusion site pain, the dosing simulations suggest effective administration levels for pediatric patients comparable to adults.
We assessed the pharmacokinetics and safety of solithromycin, a fluoroketolide antibiotic, in a phase 1, open-label, multicenter study of 13 adolescents with suspected or confirmed bacterial infections. On days 3 to 5, the mean (standard deviation) maximum plasma concentration and area under the concentration versus time curve from 0 to 24 h were 0.74 μg/ml (0.
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