Publications by Theresa Hiltner

Publications by authors named "Theresa Hiltner"

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Microsatellite instability and sex-specific differences of survival in gastric cancer after neoadjuvant chemotherapy without and with taxane: An observational study in real world patients.

Theresa Hiltner Meike Kohlruss Anna-Lina Herz Sylvie Lorenzen Alexander Novotny

J Cancer Res Clin Oncol

August 2023

Article Synopsis

The study looked at how the survival of patients with stomach cancer relates to their gender and a condition called microsatellite instability (MSI) when treated with certain chemotherapy drugs.
They found that females without a specific drug (taxane) tended to live longer than males, but this wasn't the case when patients received taxane.
Overall, having MSI-High was linked to a better chance of survival for both groups, especially for women without taxane treatment.

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Significant Tumor Regression after Neoadjuvant Chemotherapy in Gastric Cancer, but Poor Survival of the Patient? Role of MHC Class I Alterations.

Theresa Hiltner Noémi Szörenyi Meike Kohlruss Alexander Hapfelmeier Anna-Lina Herz

Cancers (Basel)

January 2023

We aimed to determine the clinical and prognostic relevance of allelic imbalance (AI) of the major histocompatibility complex (MHC) class I genes, encompassing the human leukocyte antigen (HLA) class I and beta-2 microglobulin (B2M) genes, in the context of neoadjuvant platinum/fluoropyrimidine chemotherapy (CTx). Biopsies before CTx were studied in 158 patients with adenocarcinoma of the stomach or gastroesophageal junction. The response was histopathologically evaluated.

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