Publications by authors named "Theresa Gather"
Immune protection against reinfection with nonprimate hepacivirus.
Proc Natl Acad Sci U S A
March 2017
Hepatitis C virus (HCV) displays a restricted host species tropism and only humans and chimpanzees are susceptible to infection. A robust immunocompetent animal model is still lacking, hampering mechanistic analysis of virus pathogenesis, immune control, and prophylactic vaccine development. The closest homolog of HCV is the equine nonprimate hepacivirus (NPHV), which shares similar features with HCV and thus represents an animal model to study hepacivirus infections in their natural hosts.
View Article and Find Full Text PDFThe recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evaluated.
View Article and Find Full Text PDFArticle Synopsis
- - Non-primate hepacivirus (NPHV) is a recently discovered virus similar to hepatitis C virus (HCV) that infects horses, but little is known about how it's transmitted.
- - A study monitored 20 Thoroughbred broodmares and their foals over six months after childbirth to explore possible vertical transmission of NPHV, taking various blood samples for analysis.
- - Results showed that vertical transmission did occur in one mare-foal pair, while other NPHV isolates found in newly infected foals indicated that horizontal transmission might also be occurring within the herd.