Publications by authors named "Theresa Charlotte Christ"
Article Synopsis
- The study established that the neonatal Fc receptor (FcRn) is crucial for maintaining natural IgG antibodies during VSV infection, which helps control the virus early on.
- Mice without FcRn showed reduced levels of natural antibodies, resulting in increased virus spread and ultimately fatal outcomes.
- Administering natural IgG or pre-vaccinating FcRn-deficient mice provided protection against VSV, highlighting the key role of natural antibodies in combating viral infections.
Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses. In the current study, we investigated the role of Usp22 deficiency in acute viral infection with lymphocytic choriomeningitis virus (LCMV).
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