Publications by authors named "Theresa Charity"
Mol Imaging Biol
June 2024
Article Synopsis
- Tumor hypoxia significantly reduces the effectiveness of radiation therapy, with areas of low oxygen being three times less responsive to treatment than areas with normal oxygen levels.
- This study employed a specialized imaging technique called electron paramagnetic resonance oxygen-imager (EPROI) to measure tumor oxygen levels in two mouse tumor models, revealing that the sarcoma model more accurately reflects human tumors.
- Results showed that the high levels of hypoxia in sarcomas make them more resistant to radiation, and treatment with the mitochondrial inhibitor papaverine did not enhance radiosensitivity in either tumor model.*
