Publications by authors named "Theresa B Huwar"
Introduction: Cardiac toxicity, manifested as diminished contractility, ischemic heart disease, and heart failure is a major issue in drug safety. Concerns revolve around targeted drugs (TKIs) where contractility effects were not anticipated. The ability to predict cardiac toxicity early would help to de-risk drugs in development and prepare physicians to manage risk in the clinic.
View Article and Find Full Text PDFStudies have confirmed the key role of Bacillus anthracis protective antigen (PA) in the US and UK human anthrax vaccines. However, given the tripartite nature of the toxin, other components, including lethal factor (LF), are also likely to contribute to protection. We examined the antibody and T cell responses to PA and LF in human volunteers immunized with the UK anthrax vaccine (AVP).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates T cell responses in patients who recovered from cutaneous anthrax in Turkey, focusing on the immune effects of Bacillus anthracis toxins.
- Findings indicate that strong T cell memory persists years after antibiotic treatment without the expected declines in immunity.
- Notably, the study identifies lethal factor (LF) domain IV as a key target for T cell immunity, differing between natural infection and vaccination, highlighting its importance in understanding immune responses to bacterial infections.