Fourier Transform Infrared Spectroscopy in the Study of Discrimination of Lobular Breast Cancers.

Background/aim: The early diagnosis of breast cancer plays an important role in reducing mortality and optimizing the prognosis of the disease. The existing visual and histopathological methods do not give any information at a molecular level. Fourier transform infrared spectroscopy does not require any preparation, such as fixation and histological stains.

The Influence of Sepsis on the Molecular Structure of Bones: A Fourier Transform Infrared Spectroscopy Study.

Fourier transform infrared spectroscopy was used to evaluate the molecular structure of bone tissues of patients who underwent revision of total hip and shoulder arthroplasty. The intensity increase of the spectral bands in the region of 3000-2850 cm-1 provided information about the increase of the lipophilic environment, which supported the formation of aggregates and amyloid protein formation. The appearance and the intensity increase of the "marker band" at 1744 cm-1 suggested protein peroxidation and inflammation progression.

Infrared Spectroscopic Study and Mathematical Simulations of Carotid Atherosclerosis.

Background/aim: The pathogenesis, treatment and prevention of atherosclerosis continue to be the subject of intensive research and study by the scientific community. Based on Fourier-transform infrared spectra and 3D-Doppler echogram, we attempted to develop a computational simulation model for predicting the association of atherosclerotic risk factors with pathogenic molecular structural changes.

Materials And Methods: Atheromatic carotid arteries from 56 patients (60-85 years old) were used as samples.

Infrared and Raman Spectroscopic Studies of Molecular Disorders in Skin Cancer.

Aim: To investigate the molecular structural disorders of cancerous skin.

Materials And Methods: Human malignant melanoma and basal cell carcinoma biopsies were used for the investigation. Fourier transform infrared (FT-IR), Raman spectroscopy, and scanning electron microscopy were utilized.

Oxidative stress in ageing and disease development studied by FT-IR spectroscopy.

FT-IR spectroscopy was used to investigate the effect of oxidative stress and to approach the mechanism on cancer bone demineralization, aortic valve mineralization and heterotopic ossification on disease development. The FT-IR spectra obtained from paediatric, adult bone and ex vivo irradiated adult healthy bone with a dose of 20Gy were compared with those of healthy bone. The increase of band intensity changes of vasCHvsCH in the region 3000-2850cm depended on aging, the disease progression and the dose of irradiation.

FT-IR Spectroscopy Study in Early Diagnosis of Skin Cancer.

Background/aim: Mid-infrared spectroscopy (4000-500 cm) was used to analyze the spectral changes and differences of the characteristic absorption bands of the skin components due to cancer development for early clinical diagnosis.

Materials And Methods: Human biopsies from basal cell carcinoma, malignant melanoma, and nevus were used, while normal skin tissue served as a control.

Results: The high quality of Fourier-transform infrared (FT-IR) spectra showed that upon cancer development the intensity of the absorption band at approximately 3062 cm was increased, indicating that most of the proteins had the configuration of amide B and the β-sheet protein structure predominated.

An FT-IR Spectral Analysis of the Effects of γ-Radiation on Normal and Cancerous Cartilage.

In the present study we used non-distractive physicochemical methods to investigate the effect of γ-radiation on human articular cartilage. Comparison between the FT-IR (Fourier transform infrared) spectra before and after irradiation of the cartilage with different doses of radiation showed considerable changes in the spectra. It was found that for doses up to 2 Gy the collagen helices changed their structure from α-helix to random coil.

Geographical information systems and air pollution simulation for Megalopolis' electric power plant in Peloponnese, Greece.

The growth and sophistication of geographic information systems (GIS) have propelled us into a new era of environmental analyses. Air pollution is a growing concern in populated areas as many recent studies have associated high levels of pollution with increased illnesses and mortality. The study will focus on the toxicity levels incurred by radioactive lignite-burning Power Generation facilities located in Megalopolis, Greece.

Mortality and pollution in several Greek cities.

This study examined the atmospheric pollution created by industry and traffic areas nearby the city of Kavala and the mortality of citizens in the region. The mortality data spanned over a period of 30 years. The statistical data on mortality was collected from 1968 to 1998.