Engineered Nano-Bio Interfaces for Stem Cell Therapy.

Engineered nanomaterials (ENMs) with different topographies provide effective nano-bio interfaces for controlling the differentiation of stem cells. The interaction of stem cells with nanoscale topographies and chemical cues in their microenvironment at the nano-bio interface can guide their fate. The use of nanotopographical cues, in particular nanorods, nanopillars, nanogrooves, nanofibers, and nanopits, as well as biochemical forces mediated factors, including growth factors, cytokines, and extracellular matrix proteins, can significantly impact stem cell differentiation.

Progress on the development of a metal salt-assisted ionization source for the mass spectrometric analysis of polymers.

The mass spectrometric analysis of polymers has been addressed as a challenging research topic due to poor ionization and complicated analysis using conventional mass spectrometry. The ionization source has demonstrated a promising future in rapid mass spectrometric analysis. Soft ionization techniques, such as electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) are the most ionization sources appeared to be a powerful tools for polymer characterization when combined with MS.

Correction: Metal salt assisted electrospray ionization mass spectrometry for the soft ionization of GAP polymers in negative ion mode.

Correction for 'Metal salt assisted electrospray ionization mass spectrometry for the soft ionization of GAP polymers in negative ion mode' by Theoneste Muyizere et al., Analyst, 2020, 145, 34-45.

Metal salt assisted electrospray ionization mass spectrometry for the soft ionization of GAP polymers in negative ion mode.

Glycidyl azide polymers (GAP) are one of the most important energetic polymers, but it is still a challenge to elucidate their structures using mass spectrometry due to their fragility upon ionization. Herein we developed a soft metal salt assisted electrospray ionization (MSAESI) to characterize directly GAP polymers using mass spectrometry. This technique combines paper spray ionization and the complexing effect of anions from metal salts with GAP in the negative ion mode to softly ionize GAP polymers prior to mass spectrometry analysis.

Development of paper substrate for paper spray MS in high-sensitivity analysis of biological samples.

Paper spray (PS) has demonstrated a promising future for direct mass spectrometric analysis. In the process of PS, paper substrate has been demonstrated as a crucial factor in determining the final performance of PS-MS, and therefore much attention is paid to modification of paper substrate. In this review, we systematically introduce the development of paper substrate for PS.