The Influence of the Auxiliary Ligand in Monofunctional Pt(II) Anticancer Complexes on the DNA Backbone.

Monofunctional platinum complexes offer a promising alternative to cisplatin in cancer chemotherapy, showing a unique mechanism of action. Their ability to induce minor helix distortions effectively inhibits DNA transcription. In our study, we synthesized and characterized three monofunctional Pt(II) complexes with the general formula [Pt(en)(L)Cl]NO, where en = ethylenediamine, and L = pyridine (py), 2-methylpyridine (2-mepy), and 2-phenylpyridine (2-phpy).

NMR Analysis of Extra Virgin Olive Oil of the Epirus Region of Greece with Emphasis on Selected Phenolic Compounds.

Extra virgin olive oil (EVOO) is recognized for its numerous health benefits, attributed to its rich phenolic components. NMR has emerged as a prevalent technique for precisely identifying these compounds. Among Mediterranean countries, Greece stands as the third-largest producer of olives, with the Epirus region notably advancing in olive cultivation, contributing significantly to the dynamic growth of the region.

Synthesis and Characterization of Ruthenium-Paraphenylene-Cyclopentadienyl Full-Sandwich Complexes: Cytotoxic Activity against A549 Lung Cancer Cell Line and DNA Binding Properties.

Novel full-sandwich (-Cp)-Ru-paraphenylene complexes with the general formula [(-Cp)Ru(-L)](PF) where n = 1-3 and L = biphenyl, -terphenyl and -quaterphenyl, were synthesized and characterized by means of spectroscopic and analytical techniques. The structures of the complexes [(-Cp)Ru(-biphenyl)](PF) (), [(-Cp)Ru(-terphenyl)](PF) () and [(-Cp)Ru(-terphenyl)](PF) () was determined by X-ray single crystal methods. The interaction of the complexes [(-Cp)Ru(-quaterphenyl)]Cl, ()Cl, and [(-Cp)Ru(-quaterphenyl)]Cl, ()Cl, with the DNA duplex d(5'-CGCGAATTCGCG-3') was studied using NMR techniques.

Synthesis, characterization, interactions with the DNA duplex dodecamer d(5'-CGCGAATTCGCG-3') and cytotoxicity of binuclear η-arene-Ru(II) complexes.

The novel binuclear η-arene-Ru(II) complexes with the general formula {[(η-cym)Ru(L)](μ-BL)}(PF), and their corresponding water soluble {[(η-cym)Ru(L)](μ-BL)}Cl, where cym = -cymene, L = 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen), BL = 4,4'-bipyridine (BL-1), 1,2-bis(4-pyridyl)ethane (BL-2) and 1,3-bis(4-pyridyl)propane (BL-3), were synthesized and characterized. The structure of {[(η-cym)Ru(phen)](μ-BL-1)}(PF) was determined by X-ray single crystal methods. The interaction of {[(η-cym)Ru(phen)](μ-BL-)}Cl ( = 1, 2, 3; (4), (5) and (6) correspondingly) with the DNA duplex d(5'-CGCGAATTCGCG-3') was studied by means of NMR techniques and fluorescence titrations.

Synthesis, characterization, interactions with 9-MeG and cytotoxic activity of heterobimetallic Ru-Pt complexes bridged with 2, 2'-bipyrimidine.

The complexes [(η-bz)Ru(bpm)Cl]PF, (1)PF, [(η-bz)ClRu(μ-bpm)PtCl]PF, (2)PF, [(η-cym)ClRu(μ-bpm)PtCl]PF, (3)PF, [(η-cym)ClRu(μ-bpm)PdCl]PF, (4)PF, [Pt(bpm)(cbdca)], (5) and [(η-cym)ClRu(μ-bpm)Pt(cbdca)]PF, (6)PF, (bz = benzene, bpm = 2,2'-bipyrimidine, cym = p-cymene, cbdcaH = 1,1-cyclobutanedicarboxylic acid),were synthesized and characterized by means of H NMR and high-resolution ESI mass spectrometry. The complexes were transformed to the corresponding chloride salts to become soluble in aqueous media, and to be studied regarding their biological properties. However, while the heterobimetallic complexes (3)Cl and (6)Cl were almost stable, (2)Cl and (4)Cl were decomposed.

Synthesis, reactivity and characterization of Pt(ii) complexes with N,N' chelating ligands; structure and dimethylsulfoxide reactivity relationship.

Platinum(ii) complexes of the formula PtLCl [L = 2-(2'-pyridyl)quinoxaline, (pqx) (1), 2,(2'-pyridyl)benzo[g]quinoxaline, (pbqx) (3) and 2,(2'-pyridyl)quinoline, (pqn) (5)] were synthesized and characterized by spectroscopic and X-ray diffraction methods. Also, monodentate coordination of the ligands pqx and pbqx formed the complexes trans-Pt(DMSO)pqxCl (2) and trans-Pt(DMSO)pbqxCl (4) as it is indicated from X-ray crystal structure and NMR studies. The reaction of the complexes (1), (3) and (5) with DMSO-d revealed a ligand-release solvolysis, which was studied by means of NMR techniques.