The functional consequences of sodium channel Na 1.8 in human left ventricular hypertrophy.

Aims: In hypertrophy and heart failure, the proarrhythmic persistent Na current (I ) is enhanced. We aimed to investigate the electrophysiological role of neuronal sodium channel Na 1.8 in human hypertrophied myocardium.

Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.

Aims: In heart failure (HF), enhanced persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. However, the underlying regulatory mechanisms remain unclear. Our aim was to potentially investigate the regulation and electrophysiological contribution of neuronal sodium channel NaV1.