Publications by authors named "Theodore Mobach"
Introduction/aims: Neuromuscular ultrasound (NMUS) is gaining prominence as a valuable tool for diagnosing neuromuscular disorders at the point of care. Neuromuscular disorder diagnostic criteria guidelines have begun incorporating NMUS findings. As interest grows, fellowship programs must consider incorporating training into their curricula.
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- Guillain-Barré syndrome (GBS) and myasthenia gravis (MG) are key causes of acute neuromuscular respiratory failure that often lead to ICU admissions, and this review focuses on predicting and managing these conditions.* -
- A comprehensive evaluation approach that combines patient history, physical examination, and specific tests is essential for accurately assessing the risk of respiratory failure, with tools like the Erasmus GBS Respiratory Insufficiency Score being particularly useful for GBS cases.* -
- Noninvasive ventilation can help in MG, but caution is advised in early GBS; early tracheostomy may be beneficial in MG, and despite prolonged ventilation, patients can still achieve good functional outcomes.*
Article Synopsis
- The study investigates the safety, tolerability, and pharmacokinetics of BIIB078, an investigational treatment targeting the genetic cause of amyotrophic lateral sclerosis (ALS) linked to the C9orf72 gene mutation.
- The trial involved 106 participants with C9orf72-associated ALS, who were randomly assigned to receive varying doses of BIIB078 or a placebo over a treatment period of three to six months.
- Results showed that all participants experienced at least one adverse event, mostly mild or moderate, indicating that while BIIB078 did pose some risks, it did not lead to a high rate of treatment discontinuation.