Publications by authors named "Theodore I Potgieter"
Antiviral Res
September 2023
Article Synopsis
- Human cytomegalovirus (HCMV) is a significant threat to immunocompromised individuals, and current antiviral treatments have limitations, including side effects and drug resistance.
- Researchers identified the viral alkaline nuclease (AN) as a new target for anti-HCMV therapy by showing that a mutant lacking the AN was less effective at spreading in cell cultures.
- A promising compound derived from thioxothiazolo[3,4-a]quinazoline was discovered to effectively inhibit HCMV replication, with one derivative (AD-51) showing strong activity against both resistant strains and other herpesviruses, indicating its potential as a new antiviral treatment.
