Publications by authors named "Theodore C Morgan"
Article Synopsis
- Water-soluble prodrug technology has potential for improving the oral bioavailability of insoluble small molecule drugs, but it's not widely used due to rapid breakdown in the gastrointestinal tract that leads to ineffective drug absorption.
- Researchers developed a new water-soluble promoiety (Sol-moiety) technology aimed at slowing the hydrolysis of prodrugs, enhancing drug absorption instead of causing precipitation.
- The effectiveness of this technology was shown by significantly improving the pharmacokinetics of drugs like enzalutamide, vemurafenib, and paclitaxel, including a successful study on a paclitaxel prodrug in a mouse model for pancreatic tumors.
