Publications by authors named "Theodora-Dafni Michalettou"
Article Synopsis
- The study examines genetic regulation of mRNA, proteins, and metabolites in blood samples from over 3,000 people, revealing that many genetic variants influence multiple molecular traits.* -
- It finds that there's a strong genetic connection between gene expression and protein levels (66.6%), and shows broad connections across various tissues, highlighting the shared genetic basis for different traits.* -
- By creating networks of known genetic variants, the research indicates that these variants are more frequently linked to gene expression rather than other molecular traits, helping to clarify the mechanisms behind genetic associations.*
The use of high linear energy transfer (LET) ionizing radiation (IR) is progressively being incorporated in radiation therapy due to its precise dose localization and high relative biological effectiveness. At the same time, these benefits of particle radiation become a high risk for astronauts in the case of inevitable cosmic radiation exposure. Nonetheless, DNA Damage Response (DDR) activated via complex DNA damage in healthy tissue, occurring from such types of radiation, may be instrumental in the induction of various chronic and late effects.
View Article and Find Full Text PDFThe use of high-dose Ionizing Radiation (IR) is currently one of the most common modalities in treatment of many types of cancer. The objective of this work was to investigate the effects of high-dose ionizing radiation on healthy human tissue, utilizing quantitative analysis of gene expression. To this end, publicly available transcriptomics datasets from human samples irradiated with a high dose of radiation and non-irradiated (control) ones were selected, and gene expression was determined using RNA-Seq data analysis.
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