Publications by authors named "Theodora S Koutsikou"
Article Synopsis
- Prostate cancer (PCa) is a common cancer in men, and this study introduces iron oxide nanoparticles (IONs) designed to target the overexpressed Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing Peptide (GRP) receptors in PCa for better treatment options.
- The researchers created different functionalized IONs that were tested for size, functionality, and radiolabeling efficiency, finding them to bind effectively to PCa cells while showing low toxicity.
- The results indicate these Tc-radiolabeled IONs are stable and could be developed as diagnostic tools for PCa using Single Photon Emission Computed Tomography (SPECT) imaging.
Prostate cancer (PCa) is the most common malignancy worldwide in men. This is a proof-of-concept study describing the development of Ga-magnetic iron oxide nanoparticles (mNP) targeting prostate specific membrane antigen (PSMA) and gastrin releasing peptide (GRPR) receptors as potential tools for diagnosis of PCa with PET/MRI. Two pharmacophores targeting PSMA, 1, and GRPR, 2, were coupled to mNPs carrying -SH (mNP-S1/2) or -NH (mNP-N1/2) groups.
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