Publications by authors named "Theodora H T Lai"

Routine antenatal care includes history, examination, and several standard laboratory tests. Other than the original objectives, the generated data is seldom utilised for screening for adverse obstetric and perinatal outcomes. Although new approaches and sophisticated tests improve prediction of complications such as pre-eclampsia, these may not be available globally.

View Article and Find Full Text PDF

Background: Non-tubal ectopic pregnancies account for < 10% of all ectopic pregnancies. Due to its rarity and wide variation in clinical practice, there is no guideline or consensus for its management. We reported our 20-year experience in the management of non-tubal ectopic pregnancies in a tertiary hospital.

View Article and Find Full Text PDF
Article Synopsis
  • Chemotherapy is important for treating gestational trophoblastic neoplasia (GTN), but its effects on fertility are not fully understood, leading to a study comparing GTN patients and those with molar pregnancies (MP).
  • The study involved 57 GTN patients and analyzed serum AMH levels before and after treatment with single-agent or combination chemotherapy, revealing that combination therapy resulted in lower levels, particularly noticeable at 12 months.
  • Despite the differences in hormone levels, pregnancy success rates were similar between the two groups, with longer times to first pregnancy for those on combination therapy, highlighting the need for careful patient counseling regarding fertility post-treatment.
View Article and Find Full Text PDF

Background: The incidence of second stage cesarean delivery has been rising globally because of the failure or the anticipated difficulty of performing instrumental delivery. Yet, the best way to interpret the figure and its optimal rate remain to be determined. This is because it is strongly influenced by the practice of other 2 modes of birth, namely cesarean delivery performed before reaching the second stage and assisted vaginal birth during the second stage.

View Article and Find Full Text PDF

Objective: This study aimed to systematically review the worldwide second-stage cesarean delivery rate concerning pre-second-stage cesarean delivery and assisted vaginal birth rates.

Data Sources: PubMed, Medline Ovid, EBSCOhost, Embase, Scopus, and Google Scholar were queried from inception to February 2023, with the following terms: "full dilatation," "second stage," and "cesarean," with their word variations. Furthermore, an additional cohort of 353,434 cases from our recently published study was included.

View Article and Find Full Text PDF

Fetal structural congenital abnormalities (SCAs) complicate 2-3% of all pregnancies. Whole-exome sequencing (WES) has been increasingly adopted prenatally when karyotyping and chromosomal microarray do not yield a diagnosis. This is a retrospective cohort study of 104 fetuses with SCAs identified on antenatal ultrasound in Hong Kong, where whole exome sequencing is performed.

View Article and Find Full Text PDF

Introduction: Fear of childbirth has a significant impact on women's well-being post-birth. It can affect the women's relationships, future reproductive choices, and their decision on their future mode of birth. The Wijma Delivery Expectancy/Experience Questionnaire (Version B) is a comprehensive instrument for the assessment of postnatal fear of childbirth.

View Article and Find Full Text PDF

Introduction: Fear of childbirth causes significant distress and impact on women's wellbeing. It contributed to the rising trend of non-medically indicated Caesarean births worldwide. The objective of this study was to translate and validate the Chinese version of the Wijma Delivery Expectancy/Experience Questionnaire (Version A) (W-DEQ-A), which is a comprehensive instrument for the assessment of fear of childbirth among antenatal women.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated the trend of stillbirths from 2009 to 2018, using the International Classification of Diseases - Perinatal Mortality (ICD-PM) to classify causes.
  • The stillbirth rate remained stable at 3.70 per 1000 total births over the examined years, with the majority (97.8%) occurring before labor.
  • The use of ICD-PM significantly reduced unexplained stillbirths from 57% to 18.5% by clarifying causes, but there are challenges with certain coding categories that need improvement.
View Article and Find Full Text PDF