Publications by authors named "Theo Y C Lam"
Article Synopsis
- Profile hidden Markov models (pHMMs) are effective tools for detecting novel or diverged viruses in metagenomic data, leading to their popularity in remote homology searches.
- This review evaluates various pHMM databases, comparing factors like size, taxonomic coverage, and model properties to help users choose the best one for viral sequence discovery.
- The study includes performance assessments using simulated and real data, offering researchers insights into each database's strengths and limits, along with practical recommendations for optimizing their findings in viral metagenomics.
Gut microbiota is the key controller of healthy aging. Hypertension and osteoarthritis (OA) are two frequently co-existing age-related pathologies in older adults. Both are associated with gut microbiota dysbiosis.
View Article and Find Full Text PDFThe role of the gut microbiota in various metabolic diseases has been widely studied. This study aims to test the hypothesis that gut microbiota dysbiosis is associated with DOCA-salt-induced hypertension, while captopril, an antihypertensive drug, is able to rebalance the gut microbiota alterations caused by hypertension. Treatment with captopril resulted in an approximate 32 mmHg reduction in systolic blood pressure (162.
View Article and Find Full Text PDFThe combined effect of acrylonitrile butadiene styrene (ABS) spherical beads and granular activated carbon (GAC) particles as fluidized media on the performance of anaerobic fluidized bed membrane bioreactor (AFMBR) was investigated. GAC particles and ABS beads were fluidized together in a single AFMBR to investigate membrane fouling and organic removal efficiency as well as energy consumption. The density difference between these two similarly sized media caused the stratified bed layer where ABS beads are fluidized above the GAC along the membrane.
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- Intermittent microaerobic digestion of lignocellulosic biomass leads to better digestibility and stability compared to strict anaerobic conditions, particularly at high organic loading rates.
- The study reveals that the genus Proteiniphilum dominates the microbial community and acts as an efficient cellulolytic bacterium, facilitating the breakdown of lignocellulose through both aerobic and anaerobic processes.
- Additionally, antioxidant enzymes and cytochromes in these microbes are linked to the management of reactive oxygen species under varying oxygen levels, which contributes to the improved digestion outcomes.
In the past decade, the characterisation of the microbial community in anaerobic digestion was primarily done by using high-throughput short-read amplicon sequencing. However, the short-read approach has inherent primer bias and low phylogenetic resolution. Our previous study using Illumina MiSeq suggested that the heterogeneity of AD microbiome was operation-driven.
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