Publications by authors named "Theo Level"
Iron Boosts Antitumor Type 1 T-cell Responses and Anti-PD1 Immunotherapy.
Cancer Immunol Res
September 2024
Article Synopsis
- Cancers evade the immune system, and effective immunotherapies, especially those targeting PD1, work by enhancing T-cell functions, particularly IFNγ production.
- While immunotherapies have improved patient outcomes, not everyone responds, necessitating alternative treatments to enhance their effectiveness.
- The study shows that iron supplementation boosts T-cell responses and enhances the effectiveness of anti-PD1 therapy in mice, indicating that combining iron with immunotherapy could improve cancer treatment outcomes.
Foxo family transcription factors are critically involved in multiple processes, such as metabolism, quiescence, cell survival and cell differentiation. Although continuous, high activity of Foxo transcription factors extends the life span of some species, the involvement of Foxo proteins in mammalian aging remains to be determined. Here, we show that Foxo1 is down-regulated with age in mouse T cells.
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