Publications by authors named "Theo Killian"
Article Synopsis
- Transitioning from a proliferative to an invasive melanoma phenotype increases vulnerability to ferroptosis, but the regulatory circuits behind this susceptibility are unclear.
- Apolipoprotein E (ApoE) was identified as a key lipid-metabolism gene that helps differentiate between ferroptosis-resistant and sensitive melanoma states by protecting invasive cells from ferroptosis-inducing agents.
- The study suggests that ApoE secretion and its expression may serve as potential biomarkers for poor response to ferroptosis in melanoma patients.
Fusion-negative rhabdomyosarcoma (FN-RMS) is the most common soft tissue sarcoma of childhood arising from undifferentiated skeletal muscle cells from uncertain origin. Currently used therapies are poorly tumor-specific and fail to tackle the molecular machinery underlying the tumorigenicity and uncontrolled proliferation of FN-RMS. We and other groups recently found that microRNAs (miRNA) network contributes to myogenic epigenetic memory and can influence pluripotent stem cell commitments.
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