Publications by authors named "Theo Imler"
Background: Sleep apnoea specific heart rate response (ΔHR) has been identified as a promising biomarker for stratifying cardiovascular (CV) risk, and predicting positive airway pressure (PAP) benefit in obstructive sleep apnoea (OSA). However, the need for prior manual scoring of respiratory events potentially limits the accessibility and reproducibility of ΔHR. We aimed to evaluate the association of pulse rate response to oxygen desaturations automatically derived from pulse oximetry (ΔHR) with CV risk in OSA.
View Article and Find Full Text PDFCentral sleep apneas (CSA) can occur de novo at high-altitude in individuals without sleep-disordered breathing at low altitude. These apneas are usually brief, lasting only 5-15 s. This report presents the first documented case of a man experiencing extreme altitude-induced CSA lasting more than 100 s in the absence of any sleep breathing disorder in normoxia.
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- * Key findings showed that higher scores on the Epworth Sleepiness Scale and the presence of insomnia symptoms were associated with a greater risk of developing MDD, with specific hazard ratios calculated for both factors.
- * Notably, men with increased rapid eye movement (REM) sleep had a higher MDD incidence, while women with higher delta power in their sleep showed a lower incidence, indicating gender differences in how sleep affects depression risk.
Article Synopsis
- Insomnia and hypersomnia are considered indicators of major depressive disorder (MDD) subtypes, but this study aimed to see if these sleep changes can be objectively measured using polysomnography (PSG).
- A total of 1820 participants underwent PSG and psychiatric interviews to determine their MDD subtype, with linear regression analysis used to identify sleep measure associations.
- Results showed that current melancholic MDD was linked to lower delta power and sleep efficiency, as well as more nighttime awakenings, while remitted unspecified MDD was associated with higher rapid eye movement density, suggesting distinct sleep patterns across MDD subtypes.
It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk. To investigate the value of pulse wave amplitude drops (PWADs), reflecting sympathetic activations and vasoreactivity, as a biomarker of cardiovascular risk in OSA. PWADs were derived from pulse oximetry-based photoplethysmography signals in three prospective cohorts: HypnoLaus ( = 1,941), the Pays-de-la-Loire Sleep Cohort (PLSC; = 6,367), and "Impact of Sleep Apnea syndrome in the evolution of Acute Coronary syndrome.
View Article and Find Full Text PDFThe evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the investigation of complex disease pathomechanisms, are increasingly relying on lung models. This is due to the progressive shift towards human-based systems for more predictive and translational research. While several cellular models are currently available for the upper airways, modelling the distal alveolar region poses several constraints that make the standardization of reliable alveolar models relatively difficult.
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