Publications by authors named "Theo Girinsky"
Purpose: Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease.
Patients And Methods: A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only.
Article Synopsis
- Late radiation enteritis is a consequence of abdominal radiation therapy, but its molecular mechanisms are not well understood.
- A study used cDNA array analysis to compare gene expression profiles between fibrotic bowel tissues from radiation enteritis patients and healthy tissues, revealing significant differences in genes related to fibrosis, stress response, inflammation, and tissue remodeling.
- The findings suggest a dynamic process of ongoing changes in the intestinal tissue due to radiation damage, particularly highlighting the Rho/HSP27/zyxin pathway's potential role in promoting fibrosis, while further research is needed to confirm these results.
Purpose: To investigate the expression of a new fibrogenic cytokine the connective tissue growth factor (CTGF) in intestinal radiation fibrosis and to characterize the mesenchymal cell subtypes involved in CTGF synthesis and collagen deposition.
Methods And Materials: Sixteen patients with radiation enteritis that occurred after radiotherapy for pelvic malignancies and 6 with histologically normal bowel entered the study. Immunohistochemistry, Western blot analysis, and real-time reverse transcriptase-polymerase chain reaction were performed to study CTGF expression, along with other known markers of radiation fibrosis: the pro-fibrogenic cytokine transforming growth factor (TGF)-beta1 and phenotypic markers of the fibroblast differentiation the alpha-sm actin (A), vimentin (V), and desmin (D).