Publications by authors named "Theo Dhote"
Background: This study sought to evaluate the impact of elexacaftor/tezacaftor/ivacaftor (ETI) on lung structural abnormalities in adults with cystic fibrosis (awCF) with a specific focus on the reversal of bronchial dilatations.
Methods: Chest computed tomography (CT) scans performed prior to and 12 months after initiation of ETI were visually reviewed for possible reversal of bronchial dilatations. AwCF with and without reversal of bronchial dilatations (the latter served as controls, with three controls per case) were selected.
Article Synopsis
- Cystic fibrosis (CF) causes lung problems due to bacteria and inflammation, leading to worse health during flare-ups.
- Researchers studied different types of immune cells called neutrophils in people with CF under stable conditions and during flare-ups, comparing them to healthy people.
- They found that during flare-ups, neutrophils from CF patients showed more signs of being active and that some specific neutrophils increased, which could help explain why patients get sicker.