Influence of the Planning Parameters of a New Algorithm on the Dosimetric Quality, Beam-On Time and Delivery Accuracy of Tomotherapy Plans.

Background: This work aimed to determine the optimum VOLO Ultra algorithm parameters for tomotherapy treatments.

Methods: 1056 treatment plans were generated with VOLO Ultra for 36 patients and six anatomical locations. The impact of varying four parameters was studied: the accelerated treatment (AT), leaf open/close time (LOT) cutoff, normal tissue objective (NTO) weight, and number of iterations.