Publications by authors named "Themis Dardiotis"
Article Synopsis
- Previous studies suggest that using antihypertensive medication in older adults may lower the overall risk of dementia, but the effects on different types of dementia, particularly Alzheimer’s disease (AD), are still uncertain.
- This research analyzed data from over 31,000 participants across multiple countries, focusing on how history of hypertension and blood pressure levels impact the risk of developing AD and non-AD types of dementia.
- The findings indicated that untreated hypertension significantly increases the risk of developing AD and non-AD dementia compared to healthy individuals, while treated hypertension showed a similar risk for non-AD but not a significant difference between treated and untreated groups.
[Not Available].
Alzheimers Dement
June 2024
Introduction: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.
Methods: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.
Importance: The utility of antihypertensives and ideal blood pressure (BP) for dementia prevention in late life remains unclear and highly contested.
Objectives: To assess the associations of hypertension history, antihypertensive use, and baseline measured BP in late life (age >60 years) with dementia and the moderating factors of age, sex, and racial group.
Data Source And Study Selection: Longitudinal, population-based studies of aging participating in the Cohort Studies of Memory in an International Consortium (COSMIC) group were included.
Article Synopsis
- Previous analyses indicated a link between social connections and cognitive health, but this study utilized individual data from a diverse international sample of over 39,000 participants to assess these impacts more comprehensively.
- Findings showed that strong social connections—both in terms of structure (like marriage and community engagement) and quality (feeling connected)—are tied to reduced risks of mild cognitive impairment, dementia, and mortality.
- Unique to Asian participants, being married or in a relationship significantly contributed to lower dementia risk, highlighting the varying importance of social factors across different cultures.