Zoning in on Tankyrases: A Brief Review on the Past, Present and Prospective Studies.

Background: Tankyrases are known for their multifunctionalities within the poly(ADPribose) polymerases family and playing vital roles in various cellular processes which include the regulation of tumour suppressors. Tankyrases, which exist in two isoforms; Tankyrase 1 and 2, are highly homologous and an integral part of the Wnt β -catenin pathway that becomes overly dysregulated when hijacked by pro-carcinogenic machineries.

Methods: In this review, we cover the distinct roles of the Tankyrase isoforms and their involvement in the disease pathogenesis.