Free-Floating Iris Pigmented Epithelial Cyst in the Anterior Chamber.

An unusual case of a free-floating peripheral pigmented cyst in the anterior chamber is presented. A 30-year-old Caucasian male presented reporting a visual defect on his right eye in prone position over the past year. Slit-lamp examination revealed a small pigmented free-floating peripheral iris cyst at the 6 o'clock position in the anterior chamber.

Somatostatin receptor activation (sst(1) -sst(5) ) differentially influences human retinal pigment epithelium cell viability.

Purpose: To investigate the differential effects of somatostatin and its receptors (sst(1-5) ) on the viability of cultured human retinal pigment epithelium (hRPE) cells.

Methods: MTT [3 (4, 5-dimethylthiazol-2yl)-2, 5 diphenyltetrazolium bromide], APO Percentage(TM) and trypan blue assays were performed to assess the mechanisms via which somatostatin (10(-10) -10(-4) m) and selective receptor (sst(1-5) ) ligands (10(-12) -10(-4) m) affect cell viability. The effect of orthovanadate (phosphatase inhibitor, 10(-7) -10(-5) m) on somatostatin's (10(-5) m) actions was examined, and western blot analysis was employed to determine the presence of ssts and phosphotyrosine phosphatase SHP-1 in human RPE cells.

Two-year results of cataract extraction with implantation of the hydrophilic acrylic B-lens.

Purpose: To evaluate the safety and efficacy of a hydrophilic acrylic intraocular lens (B-Lens((R)), Hanita, Israel) during a 2-year follow-up period.

Setting: Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba, Israel.

Patients & Methods: Slit lamp biomicroscopy, refraction, visual function and patient satisfaction were recorded in 147 patients at 1 week, and at 1, 3, 12, and 24 months after surgery.

Treatment of idiopathic orbital inflammatory disease with cyclosporine-A: a case presentation.

We present a case of idiopathic orbital inflammatory disease that was responded favorably to low-dose cyclosporine-A.

Central retinal vein occlusion after uncomplicated glaucoma filtering procedure combined with phacoemulsification.

We present a case of central retinal vein occlusion after an combined phacotrabeculectomy in a patient with advanced open angle glaucoma. Possible pathogenetic mechanisms for this complication are discussed.

Lamellar retinal hole formation following routine cataract surgery.

We present a case of a retinal hole detected after routine cataract surgery and discuss possible pathogenetic mechanisms of this complication.

Acute posterior multifocal placoid pigment epitheliopathy: outcome and visual prognosis.

Objectives: To examine the clinical outcomes and the effect of treatment in patients with acute posterior multifocal placoid pigment epitheliopathy.

Methods: Cases of acute posterior multifocal placoid pigment epitheliopathy treated at the Massachusetts Eye and Ear Infirmary from 1990 to 2002 and cases from the literature were identified. Data on visual acuity, ocular symptoms, bilateral involvement, foveal involvement at presentation, and treatment regimens were recorded.

Evaluation of potential retinal toxicity of adalimumab (Humira).

Purpose: The purpose of this study is to evaluate the retinal toxicity of two doses of adalimumab (Humira), a recombinant human IgG1 monoclonal antibody specific for human tumor necrosis factor (TNF), when injected intravitreally in rabbits.

Methods: Sixteen male pigmented rabbits (divided into two groups, eight animals per group) were used for this study. Two concentrations of adalimumab were tested: 0.

Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.

Objective: This study evaluated the incidence and types of adverse drug reactions (ADRs) associated with medications used to treat active toxoplasmic chorioretinitis.

Methods: This was a retrospective review of the clinical records of a consecutive series of patients with active toxoplasmic chorioretinitis, examined between March 1991 and August 1998. For inclusion in the review, patients had to have been diagnosed with active toxoplasmic chorioretinitis, been treated with a single drug or drug combination indicated for this condition, and been followed for at least 8 weeks.

Infliximab therapy for the treatment of refractory ocular inflammatory disease.

Objective: To report the outcomes of infliximab therapy in the treatment of ocular inflammatory disease refractory to traditional immunomodulatory therapy (IMT).

Methods: We retrospectively reviewed the medical records of 27 patients. All patients had noninfectious ocular inflammatory disease refractory to traditional IMT and received 5 mg/kg of infliximab at 2-week to 8-week intervals.

Long-term results of Ahmed glaucoma valve implantation for uveitic glaucoma.

Purpose: To present long-term outcomes of Ahmed glaucoma valve implantation for uveitic glaucoma.

Design: Interventional case series.

Methods: Retrospective chart review of 60 patients (60 eyes) with uveitic glaucoma who underwent Ahmed valve implantation over a four-year period at a tertiary uveitis referral center.

Human amniotic membrane transplantation for tube exposure after glaucoma drainage device implantation.

We present a case of conjunctival melting over the tube of a glaucoma shunt, which was successfully repaired with amniotic membrane transplantation.

Conjunctival non-caseating granulomas in a human immunodeficiency virus (HIV) positive patient attributed to sarcoidosis.

Purpose: To report a rare case of isolated ocular sarcoidosis in an HIV positive patient.

Design: Case report.

Methods: A 47-year-old HIV+ Caucasian male was referred for chronic bilateral follicular conjunctivitis.

Somatostatin for Uveitic Cystoid Macular Edema (CME).

Purpose: To report the favorable response of bilateral recalcitrant uveitic cystoid macular edema (CME) to treatment with a somatostatin analog.

Methods: Medical ophthalmic history and the results of ophthalmic examinations were recorded. Fluorescein angiography (FA) studies were reviewed.

Safety and efficacy of intravitreal triamcinolone acetonide for uveitic macular edema.

Background: To evaluate the safety and efficacy of intravitreal triamcinolone acetonide (TA) for treating macular edema secondary to non-infectious uveitis.

Methods: Retrospective review of sixteen patients (20 eyes) with chronic cystoid macular edema (CME) as a consequence of controlled intermediate uveitis, posterior uveitis, or panuveitis who received at least one intravitreal injection of TA. Main outcome measures were visual acuity (VA), intraocular pressure (IOP), formation or progression of an existing cataract, and CME resolution during the follow-up period.

Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy.

Purpose: To report the case of a patient developing fungal keratitis in the context of uncontrolled ocular cicatricial pemphigoid (OCP), which, despite intravenous immunoglobulin (IVIg) and other immunomodulatory therapy, progressed to end-stage pemphigoid, with corneal opacification, ankyloblepharon, and xerosis. Keratoprosthesis (KPro) restored functional vision for the patient.

Methods: A 39-year-old man presented with uncontrolled CP and corneal ulcer in the left eye.

Bilateral chronic anterior uveitis & neuro-ophthalmologic manifestations in a patient with Churg-Strauss syndrome: an unusual ocular presentation.

We describe a patient with Churg-Strauss syndrome (CSS) who developed bilateral chronic anterior uveitis and neuro-ophthalmologic manifestations 20 years after the onset of asthma and sinus disease. The patient was treated successfully with a combination of cyclophosphamide and prednisone, after other immunomodulatory strategies, aside from systemic prednisone, had failed.

Effect of somatostatin on nitric oxide production in human retinal pigment epithelium cell cultures.

Purpose: To investigate the presence of somatostatin and its receptors (sst(1-5) receptors) and their possible involvement in the regulation of nitric oxide (NO) production in human RPE cell cultures.

Methods: Human RPE cells (D407) were used for all studies performed. Somatostatin levels were detected by radioimmunoassay, and RT-PCR and immunocytochemistry studies were performed to identify the somatostatin receptors (sst1-sst5).

The role of lanreotide in the treatment of choroidal neovascularization secondary to age-related macular degeneration: a pilot clinical trial.

Purpose: To evaluate the role of somatostatin in the treatment of subfoveal choroidal neovascularization (CNV).

Methods: Twenty eyes of 20 patients with CNV were included in the study. Patients were randomly allocated to treatment with lanreotide (10 eyes) or placebo (10 eyes).

Epithelial ingrowth after laser in situ keratomileusis: a histopathologic study in human corneas.

Objective: To report the histopathologic findings in 4 human corneas that developed epithelial ingrowth after laser in situ keratomileusis (LASIK), at various postoperative intervals.

Methods: One specimen was obtained intraoperatively during treatment of epithelial ingrowth 2 months after LASIK (case 1). The other 3 corneal specimens were obtained after penetrating keratoplasty performed at 7 months (case 2), 20 months (case 3), and 5 years (CASE 4) after LASIK.