Publications by Thekla Mauch

Publications by authors named "Thekla Mauch"

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Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice ().

Frederick Hansen Matej Vučak Jenna Nichols Joseph Hughes Sidy Bane Thekla Mauch

J Gen Virol

August 2023

Article Synopsis

Researchers focused on cytomegaloviruses (CMVs) in Natal multimammate mice, a species found in sub-Saharan Africa and linked to zoonotic diseases like Lassa virus (LASV).
They isolated infectious CMVs from these mice and sequenced multiple genomes, identifying three distinct CMV types (MnatCMV1, MnatCMV2, and MnatCMV3) and discovering cases of coinfection.
The findings help understand CMV diversity and are aimed at developing a vaccine based on MnatCMVs to combat LASV in its animal reservoir.

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An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection.

Rory C F de Brito Kerry Holtham Jessica Roser Jack E Saunders Yvonne Wezel Thekla Mauch

Front Immunol

February 2024

Porcine reproductive and respiratory syndrome virus (PRRSV) remains a leading cause of economic loss in pig farming worldwide. Existing commercial vaccines, all based on modified live or inactivated PRRSV, fail to provide effective immunity against the highly diverse circulating strains of both PRRSV-1 and PRRSV-2. Therefore, there is an urgent need to develop more effective and broadly active PRRSV vaccines.

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