Publications by authors named "Thea L Johansen"
Article Synopsis
- PSD-95 is an important protein in neurons that helps organize signaling structures, and its function is influenced by phosphorylation, although studying this has been challenging.
- Researchers introduced specific phosphorylation sites on PSD-95 and created 11 different variants to analyze how these changes affected its interactions and the formation of protein complexes.
- They discovered that phosphorylation at Ser78 reduced phase separation with GluN2B and stargazin, while phosphorylation at Ser116 promoted phase separation with stargazin, offering new insights into how PSD-95 is regulated and how it interacts within the postsynaptic density.
