Publications by authors named "The-Anh Pham"
Article Synopsis
- The study introduces a new assay called SPOT-MAS that combines multiple analysis techniques to detect different types of cancer using circulating tumor DNA (ctDNA).
- SPOT-MAS was tested on a large group of 738 patients with various cancers and 1550 healthy controls, successfully identifying cancers with a sensitivity of 72.4% and high specificity.
- The assay performs well for early-stage cancers and shows promise for being more cost-effective compared to other ctDNA tests due to its lower sequencing depth requirements.
Article Synopsis
- - Late detection of hepatocellular carcinoma (HCC) leads to a low survival rate, but liquid biopsy assays that detect circulating tumor DNA (ctDNA) offer a potential early non-invasive detection method; however, challenges exist due to normal cell mutations and tumor diversity.
- - Researchers developed a classification model using deep sequencing of 13 HCC-associated genes, analyzing ctDNA fragment length profiles to distinguish between HCC patients and healthy individuals.
- - The model demonstrated strong performance in identifying HCC, with an AUC of 0.88 and 89% sensitivity in the discovery cohort, and similar results in an independent validation cohort, indicating potential for further clinical studies.
Article Synopsis
- * Researchers identified unique methylation markers from cell-free DNA of HCC patients and used them to train machine learning models, which successfully differentiated HCC patients from high-risk individuals without the cancer in testing.
- * By integrating these methylation markers with existing serum biomarkers in a commercial test, they achieved improved detection accuracy for HCC, demonstrating potential for early diagnosis.
This study aimed to evaluate the miscibility of cellulose derivatives to improve the release rate and stability of microparticles containing the weakly basic drug itraconazole (ITZ). We also investigated the effect of some organic acids on the microenvironmental pH (pH) and the release rate of ITZ from the cellulose-based microparticles. The synergistic effect of cellulose-based microparticles and pH modulators on the bioavailability of ITZ compared with the reference product was investigated in a rabbit model.
View Article and Find Full Text PDFThis paper concentrates on developing an effective approach for decompressing JPEG document images. Our main goal is targeted to time-critical applications, especially to those situated on mobile network infrastructures. To this aim, the proposed approach is designed to work either in the transform domain or image spatial plane.
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