Publications by authors named "Thavakumar Subramaniam"

Article Synopsis
  • - The study examines the effectiveness of a treatment strategy combining neoadjuvant chemotherapy (NECTORS) followed by surgery in preventing distant metastasis (DM) in patients with HPV-related oropharyngeal cancer, compared to standard care with concurrent chemoradiation (CCRT).
  • - It includes 342 patients with advanced HPV-positive OPSCC, showing that NECTORS resulted in no cases of distant-only metastasis and fewer overall recurrences than CCRT.
  • - The analysis considers various factors like age, sex, and cancer stage to assess DM-free survival rates, highlighting the potential benefits of NECTORS in reducing treatment-related toxicity.
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Major head and neck surgery poses a threat to perioperative airway patency. Adverse airway events are associated with significant morbidity, potentially leading to hypoxic brain injury and even death. Following a review of the literature, recommendations regarding airway management in head and neck surgery were developed with multicenter, multidisciplinary agreement among all Irish head and neck units.

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Article Synopsis
  • The incidence of oropharyngeal squamous cell carcinoma is rising in North America, largely due to infections from the human papillomavirus (HPV), affecting mostly younger patients and showing better survival rates compared to other head and neck cancers.
  • Current treatment options result in significant long-term side effects, prompting a shift in focus from just survival rates (mortality) to also considering patients' quality of life through patient-reported outcomes.
  • Ongoing research includes various clinical trials aimed at exploring new treatment methods or strategies to reduce side effects while still ensuring effective survival rates, with this review summarizing the latest findings in the field.
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Parathyroid cysts are a rare clinical entity that may arise in the neck or mediastinum. They are more common in women and generally present in the fourth and fifth decades of life. Diagnosis of parathyroid cysts is challenging, and despite thorough radiological and cytological investigation, they are often mistaken for thyroid pathology.

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Tinnitus is a phantom auditory perception coded in the brain that can be bothersome or debilitating, affecting 10 to 15% of the population. Currently, there is no clinically recommended drug or device treatment for this major health condition. Animal research has revealed that sound paired with electrical somatosensory stimulation can drive extensive plasticity within the brain for tinnitus treatment.

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 Evaluation of the changing trends in esthesioneuroblastoma in an Irish context and review of management options nationally to clarify the best current therapeutic approach by comparing with international research on this uncommon malignancy.  Retrospective review.  Tertiary referral center.

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Introduction: The laryngeal mask airway (LMA) is a safe method to establish airway control during general anaesthesia. In otolaryngology surgery, the use of a LMA is well established in ear surgery; however, the use of a LMA during open neck procedures remains controversial. We report a case in which the pharyngeal distortion by the LMA cuff resulted in an iatrogenic complication.

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Sternal dehiscence is a recognised complication after median sternotomy, occurring in 0.5-5% of cases with or without infection. A 72-year-old man presenting with collapse and ventricular tachycardia was investigated for a possible acute cardiac event 2 years after coronary artery bypass grafting for ischemic heart disease.

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A 37-year-old male athlete was diagnosed with primary tracheal adenoid cystic carcinoma following investigation for dyspnea, wheeze, and eventual stridor. Preoperative bronchoscopy revealed a highly vascular tumor 4 cm distal to the cricoid with no gross disease extending to the carina. Imaging revealed circumferential tracheal irregularity immediately inferior to the cricoid, with no definite cricoid invasion.

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