Synthesis, characterization and drug release of biocompatible/biodegradable non-toxic poly(urethane urea)s based on poly(epsilon-caprolactone)s and lysine-based diisocyanate.

Segmented poly(urethane urea)s (SPUUs) based on aliphatic diisocyanato (2,6-diisocyanato methyl caproate (lysine-based diisocyanate, LDI)), poly(epsilon-caprolactone diol)s (PCLs) with molecular weights 530, 1250 and 2000, and 1,4-butanediamine were synthesized in absence of catalyst. The resulting SPUUs, with different soft segment length, were characterized by suitable analytical techniques. The synthesized SPUUs had high molecular weights, low glass-transition temperatures ( View Article and Find Full Text PDF

UV curable polyester polyol acrylate/bentonite nanocomposites: synthesis, characterization, and drug release.

Polyesterpolyolacrylate/bentonite nanocomposites, capable of in situ photo polymerization, were synthesized and characterized. The organically modified bentonite clay was prepared by an ion exchange process, in which sodium ions were replaced by alkyl ammonium ions. Organo modification of bentonite was confirmed from X-ray diffraction and fourier transform-infrared data.

Cyclodextrin complexation for affinity-based antibiotic delivery.

Novel beta-cyclodextrin polymer (CD)-based drug delivery hydrogels were prepared by varying type and concentration of crosslinkers and optimizing the gel synthesis conditions. For comparison, dextrose gels were prepared using the same crosslinkers. The optimized gels were characterized by Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), and X-ray diffraction (XRD) as well as swelling and release studies.

Synthesis and characterization of semi-interpenetrating polymer networks based on polyurethane and N-isopropylacrylamide for wound dressing.

Thermosensitive semi-interpenetrating polymer networks (semi-IPNs) composed of crosslinked poly(N-isopropylacrylamide) (PNiPAAm) and linear segmented polyurethane urea (SPUU) were synthesized via thermal initiated free radical polymerization. Synthesized semi-IPNs of various compositions were characterized by Fourier transform infrared spectroscopy, water equilibrium swelling at different temperatures, drug lading, drug release, cell adhesion, and detachment. The semi-IPN films of all the compositions were transparent in dry state and negative thermosensitivity in their swelling ratio, that is, lower swelling levels with increasing temperature.