Miliutine C methyl ester, a new drimane sesquiterpene and bioactive alkaloids from the stems of .

Previous results from the our research group have isolated numerous compounds, including novel ones, but the anticancer activity of has not been demonstrated. In this study, from the most active ethyl acetate extract of the stems of , seven compounds were isolated and determined structures, including a new drimane sesquiterpenoid compound named miliutine C methyl ester () and three bioactive alkaloids (-). These three alkaloids (-) exhibited strong anticancer activities against various cancer cell lines such as MCF-7, HepG2, HeLa, NCI H460 and normal fibroblasts.

Miliutine A acid, a new cyclofarnesane sesquiterpene from the stems of .

Six compounds were isolated from the ethyl acetate extract of the stems of , including miliutine A acid (), a new cyclofarnesane sesquiterpenoid; miliutine B methyl ester (), a cyclofarnesane sesquiterpenoid which was determined the absolute configuration for the first time and four known phenol derivatives (-). NMR spectroscopic and mass spectrometry were used for identifying relative configurations. The assignments of the absolute configurations were determined based on Electronic Circular Dichroism (ECD) and NOESY spectra analysis.

Nepetifoliol - a new glutinane-triterpenoid from .

A new glutinane-triterpenoid, nepetifoliol (), together with two known compounds, dymacrin D (), and (+)-ar-tumerone () were isolated from the -hexane extract of the aerial parts of . Their chemical structures were elucidated by spectroscopic data analysis as well as the comparison of their NMR data with the ones published in the literatures. A putative biosynthetic pathway for the formation of the new compound (diaxial-5,6-diol) () from the precursor triterpene glutinol was proposed.

Utilization of Crab Waste for Cost-Effective Bioproduction of Prodigiosin.

This study aimed to establish the culture process for the cost-effective production of prodigiosin (PG) from demineralized crab shell powder (de-CSP), a fishery processing byproduct created via fermentation. Among the tested PG-producing strains, TNU02 was demonstrated to be the most active strain. Various ratios of protein/de-CSP were used as the sources of C/N for PG biosynthesis.

Wedelolides A and B: novel sesquiterpene delta-lactones, (9R)-eudesman-9,12-olides, from Wedelia trilobata.

Two new sesquiterpene lactones, wedelolides A (1) and B (2), were isolated by bioassay-guided fractionation from the leaves of Wedelia trilobata, together with known trilobolides 6-O-isobutyrate (3) and 6-O-methacrylate (4). The compounds 1 and 2 were the first examples of an unprecedented framework: a novel sesquiterpene delta-lactone, (9R)-eudesman-9,12-olide. The structures of the antimalarial wedelolides A (1) and B (2) were determined on the basis of MS and 2D NMR spectral analysis.

Schiff bases of gossypol: an NMR and DFT study.

Schiff bases of gossypol with benzylamine, methylamine, 4-aminoacetophenone and 4-fluoroaniline have been synthesized and characterized by NMR spectroscopy. All the Schiff bases of gossypol are in the enamine form according to (3)J(HC,NH) and (1)J(N,H) coupling constants. The spectra are basically unchanged by change of solvent (CD(2)Cl(2), THF-d(8) and CD(3)OD) and by variation of temperature.