Publications by authors named "Thassya F O Santos"
Vestibular rehabilitation (VR) is a therapeutic approach that minimizes the impacts of balance alterations by enhancing the central vestibular compensation mechanism. The present study investigates the effect of repeated balance exercises on the central vestibular compensation mechanism in a reserpine-induced progressive model of parkinsonism in aged rats. Male Wistar rats were assigned to three cohort experiments: Exp 1: repeated balance exercises (narrow beam test) - performed every 48 h during 20 days; Exp 2: balance exercises performed on the 0 and 8 days; Exp 3: balance exercises performed only on the 0 and 20 days.
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- Parkinson's disease (PD) is a neurodegenerative disorder linked to the loss of dopamine-producing neurons, with animal models typically using younger subjects, resulting in potential biases in research.
- A study was conducted using both adult and elderly male rats to assess the impact of age on parkinsonism induced by reserpine (RES), with evaluations based on behavior tests and weight assessments over a 30-day period.
- Results indicated that elderly rats experienced more severe catalepsy and slower symptom development than adult rats, while both age groups suffered weight loss, highlighting significant differences in how PD manifests with age.
The purpose of the present study was to investigate balance alterations and the possible role of the cholinergic neurons in the pedunculopontine nucleus (PPN) in the early stages of a progressive animal model of Parkinson's disease (PD). Twenty-eight middle-aged (8-9 months) male Wistar rats received 4 or 10 subcutaneous vehicle (control, CTL) or reserpine (RES) injections (0.1 mg/kg).
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