HIV Care Seeking Pathways and Barriers to the Continuum of Care Faced by Persons Living With HIV in Rural Nepal: A Qualitative Study.

Background: The Human Immunodeficiency Virus (HIV) has a major impact on a person's social and personal lives, affecting both physical and mental health. To meet the global 95-95-95 target, it is essential to understand and address the multi-level challenges to improve the continuum of care for persons living with HIV (PLWH). This study delves into the care-seeking pathways and barriers encountered by PLWH residing in rural areas of Nepal, shedding light on the complexities of accessing and navigating the continuum of care.

LC-MS profiling and cytotoxic activity of Angiopteris helferiana against HepG2 cell line: Molecular insight to investigate anticancer agent.

Liver cancer is one of the most prevalent malignant diseases in humans and the second leading cause of cancer-related mortality globally. Angiopteris helferiana was mentioned as a possible anticancer herb according to ethnomedicinal applications. However, the molecular docking and chemical profiling of the bioactive phytoconstituents accountable for the reported anticancer action still require research.

Perceived clinical challenges when treating patients from different cultures: A study among psychiatry trainees in Norway.

The growing number of migrant patients in western countries calls for better cross-cultural competence among health providers. As workplaces, hospitals have become increasingly multicultural, and many doctors are themselves of foreign origin, including psychiatrists. The aims of this study were to explore what clinical challenges International Medical Graduates (IMGs) and native-born Norwegian doctors training in psychiatry perceived when treating patients from other cultures, and what factors might be associated with such cross-cultural challenges.

Biomedical waste management among healthcare workers in a Primary Health Centre in Sikkim, India-A KAP study.

Background: "Biomedical waste (BMW) is the waste generated during the diagnosis, treatment or immunization of human beings or animals or research activities pertaining thereto or in the production or testing of biologicals" (Management and Handling Rules, 1998 of India). As it is a source of dangerous diseases, the handlers need to have adequate knowledge about the same.

Materials And Methods: This study assessed the knowledge, attitude, and practice of biomedical waste management among healthcare workers in a Primary Health Centre and tested the association between KAP and selected variables.

Epidemiological investigation of a cholera outbreak in Nepal-India border communities: Public health implications.

Objectives: On October 4, 2021, a cholera outbreak was reported in Kapilvastu District, one of Nepal's 26 districts bordering India. This study examined the outbreak's characteristics, response efforts, and the challenges faced.

Methods: A descriptive cross-sectional design was applied for the outbreak investigation.

Optimizing topical nasal steroid application in adenoid hypertrophy: A computational fluid dynamics (CFD) analysis.

Introduction: Intranasal steroids are effective in managing adenoid hypertrophy in children, but the evidence regarding technique of use for optimal results is lacking.

Methods: CFD analysis, with discrete phase modelling was done to simulate nasal spray in nasal cavity and drug delivery in the region of adenoids. The findings were validated using a 3D model designed from CT scan of the same region.

Identifying Risk Factors for Disease Progression in Developmental Dysplasia of the Hip Using a Contralateral Hip Model.

Background: Developmental dysplasia of the hip (DDH) can cause pain and premature osteoarthritis. The risk factors and timing for disease progression in adolescents and young adults have not been fully defined. This study aimed to determine the prevalence of and risk factors for contralateral hip pain and surgery after periacetabular osteotomy (PAO) on a dysplastic hip.

Direct Oral Anticoagulants in Budd-Chiari Syndrome.

Aims: Budd-Chiari syndrome (BCS) is managed by interventions aimed at relieving hepatic venous obstruction and anticoagulation. Despite robust data supporting the tolerability and efficacy of direct oral anticoagulants (DOACs) in patients with other venous thromboembolism, its utility in BCS is not well documented. This study aims to evaluate the efficacy and tolerability of DOACs in Primary BCS from the available literature.

Examining barriers to access mental health services among patients with mental health issues in SAARC nations: A systematic review and meta-synthesis of qualitative studies.

Background: Inspite of high prevalence of mental illness in developing countries, access to health care for addressing mental health issues has several existing barriers at different levels leading to disproportionate adverse health outcomes, summarised as the three Ds of death, disability, and health-economic deficit. This study aims at examining the perspectives of patients with mental illness on barriers to access mental care.

Methods: In this study, we searched EMBASE, PubMed, Scopus and PsycNet databases.

Exploring telemedicine and organizational challenges in the healthcare system: a qualitative analysis using Grounded Theory.

Purpose: Telemedicine is a context-specific intervention that implies significant procedural changes in a health organization. The objective of the study is to explore healthcare professionals' usage of and perceptions towards telemedicine technology and identify the perceived factors and related process change, influencing the effective adoption of telemedicine from an organizational perspective.

Design/methodology/approach: The study includes multi-disciplinary commentaries of a purposive sample of 31 healthcare professionals, conducted through semi-structured qualitative interviews and employs Grounded Theory and Thematic Analysis techniques to analyze the data.

Diversity Patterns of Epiphytic Orchids Along Elevation in the Mountains of Western Nepal.

The biodiversity and distribution of epiphytic orchids are strongly influenced by their relationship with host plants, and environmental variables like elevation, slope, and local climate are key factors in determining the abundance and diversity of these orchids. The aim of this study was to examine the richness of orchid species at different elevations within the research area of Nepal. Sampling was conducted at elevations ranging from 1300 m to 2800 m above sea level, using a systematic sampling technique known as belt transects.

Exploring diet-induced ketosis with exogenous ketone supplementation as a potential intervention in post-traumatic stress disorder: a feasibility study.

Background: Post-Traumatic Stress Disorder (PTSD) is a severe and pervasive mental disorder, and patients experience numerous distressing symptoms and impairments that significantly impact their lives. In addition to being a mental disorder, PTSD is strongly associated with a wide range of metabolic abnormalities that affect the entire body. Existing treatment options of psychotherapy and medications are often ineffective.

Adverse childhood experiences leading to narcissistic personality disorder: a case report.

Background: Narcissistic personality disorder (NPD) is associated with a complex interplay of genetic, neurobiological, and environmental factors. In this case report, we discuss the association between adverse childhood experiences (ACEs) and the development of NPD in adulthood.

Case Presentation: Here, we report a clinical case of NPD to illustrate how ACEs, particularly physical and emotional neglect, combined with early life parental overvaluation, can impair emotional regulation and self-worth, contributing to the development of narcissistic traits.

Subdural Empyema in a 13-Year-Old Male With History of Head Trauma: A Case Report.

Subdural empyema is rare but serious intracranial infection characterized by accumulation of pus between dura mater and arachnoid layer. The spread of infection is typically originating from sinusitis, otitis media, or osteomyelitis. Early diagnosis by radiological imaging and prompt treatment, either by surgical intervention or by broad spectrum antibiotics are crucial to prevent life threatening complications.

A systematic review of the major risk factors for type two diabetes among Aboriginal Australians.

Background: To investigate the sociodemographic, anthropometric, biochemical, lifestyle and cardiometabolic risk factors associated with type 2 diabetes (T2D) among First Nations Australians.

Methods: A systematic review of prospective cohorts and cross-sectional studies was conducted. Electronic data sources (MEDLINE/PubMed, Embase, CINHAL, and PsycINFO) were searched for peer-reviewed articles until August 2023.

Giant Angina Bullosa Hemorrhagica of Hard Palate: A Case Report.

Angina Bullosa Hemorrhagica is characterized with rapid appearance of soft, blood-filled blisters on the mucosa of oral cavity and oropharynx. It is a benign condition, and is not associated with any systemic hematological disorder. No etiological factors have been identified and there are no established guidelines for its management.

Epigastric discomfort in a young woman: unveiling a case of CREST syndrome.

Introduction And Importance: CREST syndrome is a clinical condition seen in relation to systemic sclerosis, which meets at least three of its five clinical features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. Three of these clinical features (Raynaud's phenomenon, sclerodactyly, and esophageal dysmotility) are often present in classical subsets of SSc: limited and diffuse, and their presence alone in association does not define CREST syndrome. Laboratory findings (autoimmunity) are crucial for diagnosis.