Change in Urine Albumin-Creatinine Ratio and Occurrence of Hyperkalemia in Patients Initiating Finerenone in the United States: A Cohort Study from the FOUNTAIN platform.

Introduction: In 2021, finerenone - a novel, selective non-steroidal mineralocorticoid receptor antagonist - was approved in the US to treat adults with CKD and T2D This study aimed to describe characteristics and short-term outcomes of patients prescribed finerenone since regulatory approval.

Methods: This was a retrospective cohort study using claims and electronic health records data from the OM1 Real-World Data Cloud™. A total of 15,948 US adults with a previous diagnosis of chronic kidney disease (CKD) and type 2 diabetes who initiated 10mg or 20mg finerenone between July 2021 and August 2023 were included.

Loss of an uncharacterized mitochondrial methionine tRNA-synthetase induces mitochondrial unfolded protein response in .

Aminoacyl-tRNA synthetases (aaRSs) are essential for translation, as they charge tRNA molecules with their corresponding amino acids. Alterations in aaRSs can significantly disrupt both cytosolic and mitochondrial translation. Through a forward genetic screen for mitochondrial unfolded protein response (UPR) activators in , we identified a missense mutation (P447V) in the previously uncharacterized gene Y105E8A.

Primary spinal epidural hematoma mimicking stroke: A case report of rare diagnostic challenge.

Introduction And Importance: Spinal epidural hematoma is a rare and potentially life-threatening condition characterized by bleeding into epidural space, leading to spinal cord compression. With an incidence of approximately 1 per 1,000,000 annually, SEH requires urgent diagnosis and management to prevent irreversible neurological damage. This report highlights a case of primary spinal epidural hematoma causing acute spinal cord compression and hemiplegia mimicking stroke like features.

A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance.

Unlabelled: In pancreatic ductal adenocarcinoma cancer (PDAC) drug resistance is a severe clinical problem and patients relapse within a few months after receiving the standard-of-care chemotherapy. One contributing factor to treatment resistance is the desmoplastic nature of PDAC; the tumours are surrounded by thick layers of stroma composing up to 90% of the tumour mass. This stroma, which is mostly comprised of extracellular matrix (ECM) proteins, is secreted by cancer-associated fibroblasts (CAFs) residing in the tumour microenvironment.

Leukopenia and thrombocytopenia in dengue patients presenting in the emergency department of a tertiary center in Nepal: a cross-sectional study.

Introduction: Dengue viruses cause either symptomatic infections or asymptomatic seroconversion. Symptomatic dengue has a wide clinical spectrum ranging from self-limiting infection to severe manifestations, mostly characterized by plasma leakage with or without hemorrhage. World Health Organization classification in 2009 classified dengue into dengue without warning signs, dengue with warning signs, and severe dengue.

Real-world healthcare utilization and costs of peripheral nerve stimulation with a micro-IPG system.

Aim: To characterize real-world healthcare resource utilization (HCRU) and costs in adults with chronic pain of peripheral nerve origin treated with peripheral nerve stimulation (PNS) using the micro-implantable pulse generator (IPG).

Materials & Methods: This retrospective observational study (9/1/19-1/31/23) linked patients from the Nalu medical database to the OM1 Real-World Data Cloud (RWDC). Eligible patients received the micro-IPG implant for PNS, were identifiable in both databases, and had ≥ 12 months of RWDC pre/post-implantation claims data.

Factors affecting mental health service delivery from primary healthcare facilities of western hilly district of Nepal: a qualitative study.

Aim: To explore factors at different socioecological levels that affect mental health service delivery from primary healthcare (PHC) facilities of Arghakhanchi district, a western hilly district of Nepal.

Background: Mental health service delivery has seen four transformational shifts from Alma Ata to Astana Declaration. Mental Health Gap Action Programme has facilitated the delivery of evidence-based interventions on mental, neurological and substance use disorders by non-specialised health workers in PHC settings as well as advocated scaling up of mental healthcare through integration of mental health in PHC.

Do targeted intergovernmental fiscal transfers improve health outcomes? Evidence from Kenyan decentralization using the difference-in-differences technique.

Background: As envisioned by the 2010 Constitution, Kenya implemented a devolved system of government in March 2013, setting up 47 counties and a corresponding number of local governments. These counties differed in their levels of development. While counties such as Nairobi and Kiambu led in social and economic indicators, others such as Turkana, Mandera and Wajir were at the bottom of the list.

Thermally stable and polar zwitterionic liquid stationary phases for gas chromatography: Understanding the impact of chemical structure.

The chemical structure of nine imidazolium sulfonate and triflimide zwitterionic liquids (ZILs) were systematically tuned to increase their thermal stability for gas chromatography (GC) separations. Substituents for imidazolium and 2-phenylimidazolium cation systems, comprised of alkyl, benzyl, and oligoether groups of varying chain lengths, were studied as stationary phases in GC. Propanesulfonate, ethanesulfonate, and propanetriflimide anions were examined to understand the effect of linker length and nucleophilicity on ZIL thermal stability.

Extract from endophytic isolates stimulates seed germination of the host and protocorm development of non-host orchids.

We isolated endophytic strains from the healthy roots, stems, and leaves of to investigate their plant growth-promoting activities in vitro. Subsequently, Indole acetic acid (IAA) was quantified and the gene (responsible for IAA synthesis in fungi) was amplified and sequenced. Finally, a germination assay was performed with seeds of and a plant growth assay with protocorms of to test their plant growth-promoting activities.

Atypical presentation of spontaneous urinoma: A case report.

Spontaneous urinomas are rare, encapsulated urine collections in the retroperitoneum that occur without prior trauma or obstruction. It often presents with nonspecific abdominal symptoms, mimicking various acute abdominal pathologies. This case report describes a rare and unique instance of spontaneous urinoma secondary to pyeloureteritis, presenting with atypical clinical features that mimic acute bowel obstruction.

An unexpected cause of intractable dysphagia after 20 years following cervical spine instrumentation using bone cement alone: a case report.

Introduction And Importance: Postoperative dysphagia following anterior cervical discectomy fusion (ACDF) for cervical disc herniation is still poorly understood. Dysphagia after anterior spinal cervical approach is mild and transient. Here, the authors present a rare case suffering with severe progressive dysphagia for over 1 year after 20 years of ACDF due to expulsed bone cement abutting the esophagus which was successfully removed after reoperation.

Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract.

Transplantation of airway basal stem cells could achieve a durable cure for genetic diseases of the airway, such as cystic fibrosis and primary ciliary dyskinesia. Recent work demonstrated the potential of primary- and pluripotent stem cell (PSC)-derived basal cells to efficiently engrai into the mouse trachea aier injury. However, there are many hurdles to overcome in translating these approaches to humans including developing safe and efficient methods for delivery in larger animal models.

Imaging of Treacher Collins syndrome: A case report.

Treacher Collins syndrome, also known as mandibulofacial dysostosis, is a rare congenital disorder affecting craniofacial development. It is caused by an autosomal dominant mutation, primarily in the TCOF1 gene, which impacts the development of the first and second branchial arches. We present the case of a 12-year-old male with bilateral conductive hearing loss and deformed ears, whose clinical and imaging findings were consistent with Treacher Collins syndrome.

Successful Targeting of Somatic Alterations With Belzutifan in Two Cases.

Clear cell renal cell carcinoma (RCC) is commonly associated with alterations in the tumor suppressor gene, resulting in upregulation of hypoxia-inducible factor pathways. Immune checkpoint inhibitors and vascular endothelial growth factor inhibitors are the mainstays of systemic treatment for metastatic RCC; however, most patients encounter disease progression after the initial response. The phase 3 clinical trial LITESPARK-005-belzutifan (HIF-2α inhibitor) demonstrated improvement in progression-free survival compared with everolimus in heavily pretreated patients unselected for somatic/germline alterations (an objective response rate of 23% and a median time on therapy of 7.

Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study.

Background: While dehydration is associated with pediatric renal impairment, the regulation of hydration status can be affected by sleep. However, the interaction of hydration and sleep on kidney health remains unclear.

Methods: We conducted a cohort study among 1914 healthy primary school children from October 2018 to November 2019 in Beijing, China.

5H-benzo[c]fluorene derivative exhibits antiproliferative activity via microtubule destabilization.

Present study aimed at a single component cyclization of 2-benzylidene-1-tetralones for the preparation of 5H-benzo[c]fluorenes and their antiproliferative activity. This ring closure reaction underwent via reductive cyclization in the presence of a sodium borohydride-aluminium chloride system. Ten diverse 5H-benzo[c]fluorene derivatives were prepared and evaluated for antiproliferative activity against three human cancer cell lines by SRB assay.

Development and validation of a functional ability index for older adults: a multicohort study.

Background: The aim of this study was to develop and validate a functional ability index (FAI) that incorporates aspects of intrinsic capacity and environmental factors of older individuals based on the World Health Organization framework of healthy ageing.

Methods: Data of 7016 participants ≥60 years participating in the baseline survey of China Health and Retirement Longitudinal Study was used for the development and internal validation of the FAI. External validation was performed in a separate cohort of 1295 older individuals aged ≥60 years.

Comparative analysis of pulmonary function in school-going adolescents: Examining the impact of depression and anxiety.

Objectives: Given the rising concern over depression and anxiety among adolescents, this study aims to investigate their potential impact on respiratory health by comparing pulmonary function test (PFT) parameters between healthy adolescents and those with either depression or anxiety or those exhibiting symptoms of both depression and anxiety.

Materials And Methods: In this cross-sectional study, a random sample of school-going adolescents aged 13-18 years from various schools in Sikkim, both males and females, were selected. Depression and anxiety were assessed using the Revised Children's Anxiety and Depression Scale-25, and pulmonary function was measured using a computerised spirometer-Spirolab III.

Differential Analysis of Heart Rate Variability in School Going Adolescents: Comparing Healthy Individuals with Those Experiencing Depression and Anxiety.

Background Adolescents often struggle with depression and anxiety, which can greatly affect their well-being and functioning. Early detection is crucial for timely intervention and long-term health. Objective The objective of this study is to compare heart rate variability between depressed and anxious adolescents and their healthy peers.