Publications by authors named "Thao N Phan"
ELN missense variant in patient with mid-aortic syndrome case report.
BMC Cardiovasc Disord
December 2022
Background: Mid-aortic syndrome (MAS) is characterized by the congenital coarctation of the abdominal aorta, abdominal and limb claudication, and hypertension. The etiology of this disorder is very diverse and often manifests in conjunction with Takayasu's arteritis, Williams-Beurens syndrome, and neurofibromatosis. The isolated mid-aortic syndrome is very rare with only a few cases reported in the literature.
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- Biomacromolecules, like peptides, have complex 3D shapes that are crucial for their functions, with the hexapeptide tryptorubin A being a unique example that can exist in two unusual forms.
- Tryptorubin A is identified as the first member of a new class of peptides called atropopeptides, which are ribosomally synthesized and modified after translation.
- These atropopeptides, modified by a specific enzyme, enhance cell functions related to blood vessel formation and open new avenues for using these enzymes in biochemistry.