Unusual reaction of ()-2-[(benzo[]thia-zol-2-yl-imino)-meth-yl]-5-(di-ethyl-amino)-phenol with tri-phenyl-borane: crystal structures and optical properties.

The mol-ecular and crystal structure of ()-2-[(benzo[]thia-zol-2-yl-imino)-meth-yl]-5-(di-ethyl-amino)-phenol (CHNOS, ) and its unexpected reaction product with tri-phenyl-borane, 2,2-diphenyl-1,3-dioxa-2-borata-1,2-di-hydro-naphthalene [systematic name: ,-diethyl-2,2-diphenyl-2-1,3λ,2λ-ben-zodioxaborinin-7-amine, CHBNO, ()] are described. For , the hydroxyl group is involved in an intra-molecular hydrogen bond with the imino nitro-gen atom and the C=N bond displays an configuration. The crystal packing is characterized by layers of inversion dimers parallel to the (10) plane and chains of mol-ecule in the -axis direction formed through C-H⋯O inter-actions.

Methodological steps used by authors of systematic reviews and meta-analyses of clinical trials: a cross-sectional study.

Background: The quality of systematic reviews and meta-analyses (SR/MAs) depends on the extent of the methods used. We investigated the methodological steps used by authors of SR/MAs of clinical trials via an author survey.

Methods: We conducted an email-based cross-sectional study by contacting corresponding authors of SR/MAs that were published in 2015 and 2016 and retrieved through the PubMed database.

Efficacy of treatments in primary spontaneous pneumothorax: A systematic review and network meta-analysis of randomized clinical trials.

Background: Primary spontaneous pneumothorax (PSP) remains a significant global health problem. Despite general agreement, an official algorithm for the management of PSP still does not exist.

Objectives: Evaluating the efficacy of all available treatments in PSP.