Acylated flavonoid glycosides from Barringtonia pendula and their inhibition on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

Six new acylated flavonoid glycosides namely barringosides J - O (1-6) along with tephrokaempferoside and barringoside D were isolated from the branches and leaves of Barringtonia pendula. The structural elucidation was confirmed by extensive analysis of their spectroscopic data including HRQTOFMS, 1D and 2D NMR experiments. Moderate inhibitory effects on LPS-induced NO production in RAW264.

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam.

This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS.

Chemical composition, anti-inflammatory and cytotoxic activity of essential oils from two species ( and ) from Vietnam.

New essential oils (EOs) extracted from different parts of two species ( and ) from Vietnam were investigated for their chemical composition, anti-inflammatory and cytotoxic activity. Sixty-nine total compounds were identified in the EOs by GC/MS. The major constituent of the leaf, fruit, and root EOs from was β-caryophyllene (71.

Stigmastane-type steroid saponins from the leaves of and their -glucosidase and xanthine oxidase inhibitory activities.

Two new vernonioside K () and vernonioside L () and four known Δ stigmastane-type steroidal saponins-vernonioside B2 (), vernoniacum B (), vernonioside B1 (), and vernoamyoside A ()-were isolated from the leaves of . Their structures were determined by comprehensive spectroscopic analysis with one-dimensional nuclear magnetic resonance, two-dimensional nuclear magnetic resonance, and high-resolution mass spectrometry. All isolated compounds (-) were evaluated to determine their inhibitory effects on -glucosidase and xanthine oxidase.

Enrichment of soy isoflavone extracts through macroporous resin for characterization of toxicity and estrogenic activities.

Unlabelled: Soy isoflavone extracts are widely researched for their distinctive potential in contributing to various functional foods. The research work focuses on testing the toxicity of purified soy isoflavone extracts in mice models. With an agreement of the animal ethics, acute toxicity is firstly used to screen the effects of test compounds in mice for therapeutic purposes.

Synthesis and In Vitro Testing of YVO:Eu@silica-NH-GDA-IgG Bio-Nano Complexes for Labelling MCF-7 Breast Cancer Cells.

We present a visual tool and facile method to detect MCF-7 breast cancer cells by using YVO:Eu@silica-NH-GDA-IgG bio-nanocomplexes. To obtain these complexes, YVO:Eu nanoparticles with a uniform size of 10-25 nm have been prepared firstly by the hydrothermal process, followed by surface functionalization to be bio-compatible and conjugated with cancer cells. The YVO:Eu@silica-NH-GDA-IgG nanoparticles exhibited an enhanced red emission at 618 nm under an excitation wavelength of 355 nm and were strongly coupled with MCF-7 breast cancer cells via biological conjugation.

Chemical constituents of and their -glucosidase inhibition activity.

The first chemical study of the whole S. X. Yu & Y.

Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity.

Aplydactylonins A-C (1-3), three new sesquiterpenes, were isolated from the Vietnamese sea hare Aplysia dactylomela. Their structures and absolute configurations were elucidated based on spectroscopic analysis, X-ray crystallography, and density functional theory (DFT) calculations of NMR and ECD data. Compound 2 exhibited cytotoxicity against HepG2, DU145 and A549 cells with respective IC values of 4.

Chemical Constituents from the Leaves of Pachyrhizus erosus Collected in Vietnam.

A phytochemical investigation of methanol extract from leaves of Pachyrhizus erosus (L.) Urban, a leguminous shrub distributed in Vietnam and other tropical and subtropical countries led to the isolation of a new prenylated chalcone, erosusone (1) and a new megastigmane glycoside epimer, 3-episedumoside F (9), together with thirteen known compounds including flavonoids (2-6), a 3-benzoxepine lactone (7), a pyridine-4,5-diol derivative (8), megastigmanes and megastigmane glycosides (10-15). Their structures were elucidated by means of high resolution-electrospray ionization (HR-ESI)-MS, one dimensional (1D) and two-dimensional NMR (2D-NMR) spectroscopy as well as comparison with the data reported in the literature.

Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi.

Fourteen polyhydroxylated steroids including six new compounds, ehrensteroids A - F (1-6), were isolated from the Vietnamese soft coral Sarcophyton ehrenbergi after applying various chromatographic separations. The structure elucidation was done by detailed analysis of 1D, 2D NMR and HR QTOF mass spectra. In addition, significant cytotoxicity (IC values ranging from 8.

Chemical constituents of Tard. and their -glucosidase inhibition activities.

Sixteen compounds (-) were isolated from . Chemical structures were determined by spectroscopic analyses and comparisons with previously published data. This report is the first to identify compounds , , , , and from the genus Seven chosen isolates (, , , , , , and ) were submitted for -glucosidase inhibition assays with acarbose as the positive control (IC = 227.

Garcinoxanthones SV, new xanthone derivatives from the pericarps of Garcinia mangostana together with their cytotoxic and antioxidant activities.

Xanthones (9H-xanthene-9-ones) are considered to be very promising compounds due to a variety of interesting biological and pharmacological activities. In this study, column chromatography of the methanol extract of the Garcinia mangostana L. pericarps resulted in the isolation of four new xanthones (garcinoxanthones SV, 1-4) and five known analogs including garcinone E (5), 11-hydroxy-1-isomangostin (6) mangostenone E (7), 1,3,6,7-tetrahydroxyxanthone (8), and α-mangostin (9).

Cyclodextrin glycosyltransferase-treated germinated brown rice flour improves the cytotoxic capacity of HepG2 cell and has a positive effect on type-2 diabetic mice.

Germinated brown rice (GBR) consists of bioactive compounds (BCs) that are very useful for diabetes treatment. Modified GBR-based flour (MGBRF) was produced by modifying the starch in GBR with 0, 299.19, 598.

Polyhydroxylated steroid derivatives from the starfish .

A new polyhydroxysteroid glycoside, regulusoside D (), and a new polyhydroxylated steroid, (24)-cholestane-3,5,6,8,15,24-hexol (), together with seven known compounds were purified from the starfish collected near Con Co Islands, Vietnam. The structure elucidation was confirmed by extensive analysis of their NMR and HR-QTOF mass experiments. Among isolated compounds, regulusoside D (), (24)-cholestane-3,5,6,8,15,24-hexol (), granulatoside A (), 5-cholestane-3,6,7α,15,16,26-hexol (), 5-cholestane-3,6,7,8,15,16,26-heptol () and 5-cholestane-3,6,8,15,16,26-hexol () exhibited strong inhibitory effects on LPS-induced NO production in RAW264.

Cell Growth Inhibition of Saponin XII from Miq. on Acute Myeloid Leukemia Cells.

In previous studies, we isolated the known compound saponin XII from the roots of Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G/G phase of the cell cycle, with a decrease of cells in the S and G/M phases.

Identification Of Potential Cytotoxic Inhibitors From .

A phytochemical investigation of led to the isolation of six withanolides, including withanolide E (), withaperuvin C (), 4-hydroxywithanolide E (), 28-hydroxywithaperuvin C (), physaperuvin G (), and 4-deoxywithaperuvin (). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines.

Dendrodoristerol, a cytotoxic C20 steroid from the Vietnamese nudibranch mollusk .

Using various chromatographic separations, four steroids including one new C steroid namely dendrodoristerol (), were isolated from the Vietnamese nudibranch mollusk . The structure elucidation was confirmed by combination of spectroscopic experiments including 1D and 2D NMR, HR QTOF MS, and CD. Compound was found to exhibit significant cytotoxic activity against six human cancer cell lines as HL-60, KB, LU-1, MCF-7, LNCaP, and HepG2.

Triterpene glycosides from the Vietnamese sea cucumber .

From the MeOH extract of the Vietnamese sea cucumber , eight triterpene glycosides (-), including one new compound namely holothurin A (), were isolated by using various chromatographic separations. Their structures were established by spectroscopic experiments including 1D, 2D NMR and HR-ESI-MS. Holothurin A () has a hydroperoxy group at C-25.

Degalactotigonin, a Steroidal Glycoside from , Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells.

Degalactotigonin () and three other steroidal compounds solasodine (), -acetyl solasodine (), and soladulcoside A () were isolated from the methanolic extract of , and their chemical structures were elucidated by spectroscopic analyses. The isolated compounds were evaluated for cytotoxic activity against human pancreatic cancer cell lines (PANC1 and MIA-PaCa2) and lung cancer cell lines (A549, NCI-H1975, and NCI-H1299). Only degalactotigonin () showed potent cytotoxicity against these cancer cell lines.

Cytotoxic steroids from the Vietnamese gorgonian Verrucella corona.

Using various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A-F (1-6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidated by spectroscopic analysis, including HR QTOF MS, 1D and 2D NMR. Among isolates, verrucorosterone (7), 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-8,22-dien-7-one (14), and 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-8(14),22-dien-7-one (15) showed significant cytotoxicity (IC values ranging from 12.

The in vitro and in vivo anti-inflammatory activities of alphitonin-4-O-β-D-glucopyranoside.

The anti-inflammatory compound, alphitonin-4-O-β-D-glucopyranoside (1), has previously been isolated in the leaves of Artokapus tonkinensis and synthesised from taxifolin. This study aimed to investigate the inhibitory effect of this compound on inflammatory cytokines, including tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and IL-10, in RAW264.7 macrophages and in an arthritis animal model.

The impact of guest compounds on cyclodextrin aggregation behavior: A series of structurally related parabens.

Several studies have demonstrated the presence of aggregates in aqueous cyclodextrin containing solutions. The presence of guest compounds has been shown to influence this cyclodextrin aggregation process. In an attempt to gain insight into the effect of the physicochemical properties of the guest compound on 2-hydroxypropyl-β-cyclodextrin aggregation formation, a series of structurally related parabens was selected as model compounds.

Cytotoxic triterpene diglycosides from the sea cucumber Stichopus horrens.

Using various chromatographic separation techniques, eight triterpene diglycosides (1-8), including four new compounds namely stichorrenosides A-D (1-4), were isolated from a methanol extract of the Vietnamese sea cucumber S. horrens. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, 1D and 2D NMR.