Publications by authors named "Thao Dang Thi Thu"
Int J Infect Dis
March 2023
Article Synopsis
- HLA-B*57:01 and B*58:01 are known as protective alleles against HIV-1, specifically in relation to the TW10 epitope, but their effectiveness in combating the CRF01_AE strain prevalent in Southeast Asia is less understood.
- A study involving 280 Vietnamese individuals with CRF01_AE infection found that while most HLA-B*57:01/58:01-positive individuals had the T242N mutation, there was no significant improvement in viral load or CD4 counts compared to those without these alleles.
- Further analysis showed that although T242N reduces the viral fitness of CRF01_AE, the overall protective effect of HLA-B*57:01
Article Synopsis
- Echovirus 30 (E30) and Japanese encephalitis virus (JEV) are prevalent causes of acute meningitis in Southeast Asia, prompting a study to differentiate between them due to potential misdiagnosis, particularly during an outbreak in Vietnam (2001-2002).
- A retrospective study analyzed clinical records of 43 E30 and 60 JEV cases, comparing symptoms and clinical parameters using statistical methods.
- Results indicated that symptoms like fever, headache, and vomiting were common to both, but E30 cases showed a higher prevalence of headache and vomiting combinations, while JEV cases exhibited stronger neurological symptoms and distinct cerebrospinal fluid (CSF) profiles.
