Cerebral Artery Vasoconstriction After Galcanezumab Loading Dose for Migraine Prevention: A Case Report.

Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies that target CGRP ligands or receptors, may cause a very rare side effect of reversible cerebral vasoconstriction syndrome (RCVS). This study is a case report of a patient who developed cerebral artery vasoconstriction documented on serial brain magnetic resonance angiography (MRA) scans without the typical manifestations of RCVS following galcanezumab loading dose. Case report: A 40-year-old female patient with high-frequency episodic migraine with visual aura on topiramate 100 mg/day developed transient numbness of the right upper and lower extremities and right face without headache and a normal neurological examination 10 min after a loading dose of galcanezumab, which resolved over the next 2 days.

"Wearing-off" efficacy of CGRP monoclonal antibodies for migraine prevention: A meta-analysis of randomized controlled trials.

Background: A new migraine prevention, CGRP monoclonal antibodies (mAbs), is injectable on a monthly or quarterly basis. In clinical practice, some patients reported that drug effectiveness does not last until the upcoming scheduled injection, a so-called "wearing-off" effect. We aimed to evaluate the wearing-off effect of the CGRP mAbs for migraine prevention in patients with different monthly migraine days.

Preventive treatment response associated with migraine aura subtypes in a Thai population.

Introduction: Some studies indicate a different response to treatment between migraine patients with and without aura.

Objectives: To determine whether aura, or simple or complex aura subtypes, are clinical markers predicting response to preventive treatment.

Methods: Conducted a retrospective cohort study at a headache clinic in a tertiary referral hospital.

Factors Associated with the Incidence and Mortality of Coronavirus Disease 2019 (COVID-19) after 126-million Cases: A Meta-analysis.

Objectives: This meta-analysis was conducted to investigate the current global incidence and mortality of COVID-19 and also explored the associated factors including geographic variations, transmission scenarios, country economic status, and healthcare performance.

Methods: The search was conducted in online databases based on reports from national authorities by March 28, 2021. Random-effects model meta-analyses and meta-regression analyses were used to generate summary estimates and explored sources of heterogeneity.

The impact of phosphate lowering agents on clinical and laboratory outcomes in chronic kidney disease patients: a systematic review and meta-analysis of randomized controlled trials.

Background: Besides reducing hyperphosphatemia in chronic kidney disease (CKD) patients, phosphate lowering agents might provide beneficial effects on clinical and laboratory parameters. This meta-analysis was conducted to comprehensively examine the impact of all phosphate lowering agents on various aspects of clinical and laboratory outcomes in CKD patients.

Method: A systematic literature search was performed in MEDLINE, Scopus, and the Cochrane Register of Controlled Trials until July 2020 to identify randomized controlled trials (RCTs) which compared the effects of each phosphate lowering agent with controls, comprising placebo and all other phosphate lowering agents.

Thai-version Migraine Disability Assessment (MIDAS) questionnaire: concurrent validity, test-retest reliability, internal consistency, and factors predictive for migraine-related disability.

Background: A Thai-version of the Migraine Specific Quality of Life Questionnaire (MSQ 2.1) is available, but a qualified questionnaire used specifically for disability assessment was not available. The most relevant practical disability assessment tested during this study was the Migraine Disability Assessment (MIDAS) Questionnaire.

Reliability of the Thai Version of the Motion Sickness Susceptibility Questionnaire Short-Form.

Motion sickness is a feeling of unwellness and introduces a significant safety risk. If a specific questionnaire to screen for motion sickness susceptibility is available, it would have benefit for susceptible people. This aimed at examining test-retest reliability and internal consistency of the Thai, non-English version Motion Sickness Susceptibility Questionnaire Short-Form (MSSQ-Short).

A randomized controlled study of intravenous fluid in acute ischemic stroke.

Objective: To compare the outcome of patients with acute ischemic stroke who received or did not receive intravenous fluid.

Patients And Methods: This study was a prospective, multicenter, randomized, open-label trial with blinded outcome assessment. We enrolled acute ischemic stroke patients without dehydration aged between 18 and 85 years with NIH Stroke Scale score (NIHSS) score from 1 to 18 who presented within 72h after onset.

Movement Disorders in Non-Wilsonian Hepatic Cirrhotic Patients: The Subgroup Analysis of Various Phenotypes and Associated Risk Factors.

Objective: The aim of this subgroup analysis was to identify the risk factors associated with the development of various movement disorder phenotypes.

Methods: Eighty-three non-Wilsonian cirrhotic patients with abnormal movements were allocated into the following groups: intention tremor, bradykinesia, Parkinsonism, and abnormal ocular movements. These movement types were considered the primary outcomes as there was a sufficient sample size.

Movement Disorders in Non-Wilsonian Cirrhotic Patients: A Report of the Prevalence and Risk Factors from a Study Done in a Medical School in an Agricultural-Based Community.

Objective: Parkinsonism and other movement disorders have previously been reported in the acquired hepatocerebral degeneration associated with portosystemic shunting. However, there is no study to date about their prevalence as has been noted in general practice.

Methods: One hundred and forty-three patients with hepatic cirrhosis from the gastroenterology clinic and internal medicine wards were enrolled.

Diagnostic utility of NMO/AQP4-IgG in evaluating CNS inflammatory disease in Thai patients.

Epidemiological studies in Thailand have reported that inflammatory demyelinating diseases (IDDs) commonly affect the optic nerve and spinal cord. We investigated the diagnostic utility of aquaporin (AQP)-4-IgG testing in 31 consecutive patients evaluated for CNS IDDs in 3 academic Thai hospital neurology clinics between February 2008 and January 2009. Patients were classified into 3 clinical diagnostic groups: Neuromyelitis optica (NMO, n=10) multiple sclerosis (MS, n=5) and unclassified IDD (n=16).

The low prevalence of primary restless legs syndrome in Thai Parkinson's disease patients at Chulalongkorn University Hospital.

Objective: There have been many studies of the prevalence of restless legs syndrome (RLS) in Parkinson's disease (PD). Some studies found a lower prevalence than in comparable groups in the general population while others reported more RLS. The present study was designed to determine the prevalence of primary RLS in Thai PD patients.

A national registry to determine the distribution and prevalence of Parkinson's disease in Thailand: implications of urbanization and pesticides as risk factors for Parkinson's disease.

Background: Parkinson's disease (PD) occurs worldwide but prior to this review of data from the Thailand Parkinson's Disease Registry there had been no nationwide PD registry reported globally.

Objective: To determine the distribution and prevalence of PD in Thailand and related risk factors in order to more adequately develop and allocate prevention and treatment resources where they are most needed and to ascertain risk factors that are specific to the Thai population.

Design: The Thailand Parkinson's Disease Registry is a new resource, and data collection began in March 2008.

Potential risk factors for psychiatric disorders in patients with headache.

Background: Psychiatric comorbidities are common among patients with headache. These can compromise the quality of life of patients and may affect the result of treatment. No available systematic study concerning this problem has been conducted in Thailand.

Prevalence of neuroleptic-induced restless legs syndrome in patients taking neuroleptic drugs.

Dopamine deficiency or dopamine dysfunction has been implicated as one of the factors involved in the pathophysiology of restless legs syndrome (RLS). Our objective is to determine the prevalence of primary RLS in patients taking neuroleptic drugs. One hundred patients taking neuroleptic drugs and 100 healthy age- and sex-matched controls were interviewed with the Cambridge-Hopkins diagnostic questionnaire for RLS.

A preliminary study of chemo- and cytokine responses in rabies vaccine recipients of intradermal and intramuscular regimens.

Plasma from 10 patients who had received rabies vaccine either intradermally (ID) or intramuscularly (IM) was examined for 20 chemo- and cytokines. Plasma samples were withdrawn on days 0, 3 and 7 after vaccination. These chemo- and cytokines and sampling days were chosen based on data collected from a protein array analysis of 122 cytokines conducted on one recipient of vaccine administered IM and one recipient of vaccine administered ID.

Predictive risk factors of seizure-related injury in persons with epilepsy.

Objective: The clinical risk factors for seizure-related injuries (SRI) in adult persons with epilepsy (PWE) were studied and analyzed to develop a predictive model.

Methods: We enrolled 300 consecutive cases from three epilepsy clinics in Northeast, Thailand. Subjects were eligible if reported to have at least one seizure attack during the past 12 months.

The Thai version of the quality-of-life in epilepsy inventory (QOLIE-31-Thai version): translation, validity and reliability.

Objective: To assess the validity and reliability of the QOLIE-31-Thai Version.

Material And Method: The original questionnaire of the QOLIE-31 was first translated into Thai and, then, item comprehension was assessed. Back translation into English and cross-cultural modification were conducted.

Compliance with treatment of adult epileptics in a rural district of Thailand.

Background: Epilepsy, a disease when seizures can occur from antiepileptic drug withdrawal, requires regular drug taking. Non-compliance, therefore, is a major factor contributing to sub-optimal control of the seizures.

Purpose: To determine the factors associated with noncompliance in epileptics in rural Thailand.

Prevalence of epilepsy in rural Thailand: a population-based study.

Background: A study of the community-based burden of illness based upon prevalence is needed to plan intervention strategy.

Purpose: To determine the prevalence of epilepsy in a rural population in Thailand.

Method: From January to June, 2000, all of the people in Talardkav sub-district were invited to be interviewed and examined by a neurologist who visited their village.