Synthesis of - and enantioenriched -β-amino alcohols by highly diastereoselective borono-Mannich allylation reactions.

A highly diastereoselective method for the synthesis of -β-amino alcohols and enantioenriched -β-amino alcohols has been developed involving α-hydroxyl aldehydes and chiral α-phenylaminoxyaldehydes or α-benzoyloxyaldehydes, respectively in Petasis borono-Mannich allylation reactions. This study broadens the scope and utility of the Petasis reaction to include pinacol allylboronate and highlights its unique reactivity and stereochemical outcomes.

()-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of and their antimalarial and cytotoxic activities.

A new farnesylindole, ()-3-(8'-hydroxyfarnesyl)-indole (), as a scalemic mixture (33% ) along with nine known compounds (-), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from . All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds , and showed moderate antiplasmodial activities against TM4/8.

Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of .

A new 2-arylbenzofuran, spathobenzofuran (), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of . All compounds were characterised by spectroscopic methods. Compound was active (MIC 8 µg/mL) against Gram-negative TISTR 781 while compound had modest activity against Gram-positive TISTR 1466 with a MIC value of 16 µg/mL.

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.

Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively).

Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum.

One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated.