Development of mangiferin loaded chitosan-silica hybrid scaffolds: Physicochemical and bioactivity characterization.

Development of hybrid materials with molecular structure of organic-inorganic co-network is a promising method to enhance the stability and mechanical properties of biopolymers. Chitosan-silica hybrid nanocomposite scaffolds loaded with mangiferin, a plant-derived active compound possessing several bioactivities, were fabricated using the sol-gel synthesis and the freeze-drying processes. Investigation on the physicochemical and mechanical properties of the fabricated scaffolds showed that their properties can be improved and tailored by the formation of 3-dimensional crosslinked network and the addition of ZnO nanoparticles.

Simple Colorimetric Assay for Detection Using Aptamer-Functionalized Nanoparticles.

Simple, rapid, and sensitive screening methods are the key to prevent and control the spread of foodborne diseases. In this study, a simple visual colorimetric assay using magnetic nanoparticles (MNPs) and gold nanoparticles (AuNPs) was developed for the detection of . First, the aptamer responding to was conjugated onto the surface of MNPs and used as a specific magnetic separator.

Biocompatible zwitterionic copolymer-stabilized magnetite nanoparticles: a simple one-pot synthesis, antifouling properties and biomagnetic separation.

A simple one-pot synthesis of biocompatible and antifouling magnetite nanoparticles (FeONPs) was developed. The process involves co-precipitation and coating of zwitterionic copolymer poly[(methacrylic acid)--(2-methacryloyloxyethyl phosphorylcholine)] (PMAMPC). The influence of one-step and two-step coating methods on the performance of modified FeONP was investigated.

Non-cytotoxic hybrid bioscaffolds of chitosan-silica: Sol-gel synthesis, characterization and proposed application.

Biohybrid chitosan-silica scaffolds were synthesized through the sol-gel and the freeze drying processes. Hydrolysis and condensation of chitosan with tetraethylorthosilicate (TEOS) in the presence of 3-isocyanatopropyl triethoxysilane (ICPTES) were successfully carried out. Results obtained from FTIR, swelling test and pyrolysis confirmed that the hybrid scaffolds containing covalent coupling between the organic and inorganic networks were formed with high crosslink density of SiOSi bridging and could be classified as the class II material.